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首页> 外文期刊>Cell cycle >A direct, non-canonical pathway for Hedgehog proteins in the endothelium.
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A direct, non-canonical pathway for Hedgehog proteins in the endothelium.

机译：刺猬蛋白在内皮中的直接，非经典途径。

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摘要

The hedgehog (Hh) signaling pathway is implicated in a broad spectrum of activities, ranging from embryonic patterning to promoting angiogenesis in the adult. A common canonical paradigm has largely prevailed to explain the mode of action of Hh in such diverse types of processes. Hh ligands (Shh, Ihh and Dhh) bind to and inhibit the inhibitory action of the Hh receptor (Patched-1 or PTCHI) on Smoothened (SMO), the central transducer of the Hh pathway. The rank order ofpotency is Shh Ihh > Dhh. In the classical or canonical pathway, all signals carried by Hh proteins converge to a common family of transcription factors, termed Gli. Inhibition of phosphorylation-dependent degradation of Gli-2 and -3 proteins by Hh leads to the widespread activation of the transcription of not only cell cycle, survival and pro-angiogenic factors, but also of various members of the Hh pathway cascade, like ptch I and Gli 1 The latter activation represents the hallmark of the classical response to Hh stimulation.
机译：刺猬（Hh）信号传导途径涉及广泛的活动范围，从胚胎模式到促进成年血管生成。常见的规范范式在很大程度上解释了Hh在这种不同类型的过程中的作用方式。 Hh配体（Shh，Ihh和Dhh）与Hh受体（Patched-1或PTCHI）结合并抑制其对Hh途径的中心转导子Smoothened（SMO）的抑制作用。效能的等级顺序为Shh Ihh> Dhh。在经典途径或规范途径中，Hh蛋白携带的所有信号均会汇聚到一个称为Gli的转录因子家族中。 Hh对Gli-2和-3蛋白磷酸化依赖性降解的抑制不仅导致细胞周期，存活和促血管生成因子的转录广泛活化，而且还导致Hh途径级联的各个成员（如ptch）的转录广泛激活。 I和Gli 1后者的激活代表了对Hh刺激的经典反应的标志。

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