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首页> 外文期刊>Cell cycle >Assembly of GMPCPP-bound tubulin into helical ribbons and tubes and effect of colchicine.
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Assembly of GMPCPP-bound tubulin into helical ribbons and tubes and effect of colchicine.

机译：GMPCPP结合的微管蛋白组装成螺旋状的带子和试管，并带有秋水仙碱。

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Microtubule assembly and disassembly is a complex structural process that does not proceed by simple addition and subtraction of individual subunits to and from a helical polymer, as would be the case for actin and other helical assemblies. The dynamic process of microtubule growth and shrinking involves short-lasting polymer forms that differ substantially from the microtubule itself and constitute crucial assembly and disassembly intermediates. Structural characterization thus depends on the stabilization of these brief intermediates and their preservation as polymeric assemblies. This paper gives experimental details on the polymerization of GMPCPP-tubulin into low-temperature, stable polymers that we propose to correspond to the early stages in microtubule assembly, and includes new data on the effect of colchicine on GMPCPP-tubulin polymerization. Finally, we add our thoughts on the possible biological meaning of tubulin polymerization versatility.
机译：微管的组装和拆卸是一个复杂的结构过程，不会像在肌动蛋白和其他螺旋组件的情况下那样，通过简单地将单个子单元与螺旋聚合物进行简单的添加和减去来进行。微管生长和收缩的动态过程涉及持久的聚合物形式，这些形式与微管本身大不相同，并且构成关键的组装和拆卸中间体。因此，结构表征取决于这些短暂中间体的稳定性及其作为聚合物组装体的保存。本文提供了关于将GMPCPP-微管蛋白聚合为低温稳定聚合物的实验细节，我们建议将其对应于微管组装的早期阶段，并提供了秋水仙碱对GMPCPP-微管蛋白聚合作用的新数据。最后，我们对微管蛋白聚合多功能性的可能生物学意义添加了想法。

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