Activation of Bax by BH3 domains during apoptosis: the unfolding of a deadly plot.

Juin P; Cartron PF; Vallette FM

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Activation of Bax by BH3 domains during apoptosis: the unfolding of a deadly plot.

机译：BH3域在凋亡过程中激活Bax：致命图的展开。

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The BH3-only proteins are intracellular death ligands that are critical for initiating apoptosis. Their mode of action is dependent upon the ability of their BH3 domain to interact with pro- and anti-apoptotic multi-domain members of the Bcl-2 family. Direct agonists of the pro-apoptotic multi-domain protein Bax, and other BH3-only proteins, induce Bax activation and apoptosis by independent, yet cooperative, pathways.

机译：仅BH3蛋白是细胞内死亡配体，对启动细胞凋亡至关重要。它们的作用方式取决于其BH3结构域与Bcl-2家族的促凋亡和抗凋亡多结构域成员相互作用的能力。促凋亡多结构域蛋白Bax和其他仅BH3的蛋白的直接激动剂通过独立但合作的途径诱导Bax激活和凋亡。

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《Cell cycle》 |2005年第5期|共6页
作者
Juin P; Cartron PF; Vallette FM;
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正文语种 eng
中图分类细胞生物学;
关键词
Proto-Oncogene Proteins c-bcl-2; bcl-2-Associated X Protein; 原致癌基因蛋白质 c-bcl-2;

机译：Proto-Oncogene Proteins c-bcl-2;bcl-2-Associated X Protein;原致癌基因蛋白质 c-bcl-2;

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1. Activation of Bax by BH3 domains during apoptosis: the unfolding of a deadly plot. [J] . Juin P, Cartron PF, Vallette FM Cell cycle . 2005,第5期

机译：BH3域在凋亡过程中激活Bax：致命图的展开。
2. Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis [J] . Michela Marani, Tencho Tenev, David Hancock, Molecular and Cellular Biology . 2002,第11期

机译：直接激活Bax触发凋亡的BH3域蛋白Bim的新型同工型的鉴定。
3. Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX [J] . Bonsu Ku, Chengyu Liang, Jae U Jung, Cell research. . 2011,第4期

机译：BCL-2抑制BAX激活涉及其与BAX BH3结构域紧密且优先相互作用的证据
4. Activation of JNK/Bim/Bax pathway in UV-induced apoptosis [C] . Lei Liu, Li Hui, Zhen-zhen Zhang Biophotonics and immune responses VI . 2011

机译：JNK / Bim / Bax途径在紫外线诱导的细胞凋亡中的激活
5. The inhibition of apoptosis and Bax activation by mitochondrial anti-apoptotic proteins encoded by vaccinia virus and ectromelia virus. [D] . Taylor, John M. 2007

机译：牛痘病毒和念珠菌病毒编码的线粒体抗凋亡蛋白对细胞凋亡和Bax激活的抑制作用。
6. Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis [O] . Michela Marani, Tencho Tenev, David Hancock, 2002

机译：直接激活Bax触发凋亡的BH3域蛋白Bim的新型同工型的鉴定。
7. Activation of Bax by BH3 Domains during Apoptosis:The zunfolding of a Deadly Plot [O] . Philippe Juin, Pierre François Cartron, François M. Vallette 2005

机译：在细胞凋亡期间BH3结构域激活Bax：致命地块的Zunfolding

Activation of Bax by BH3 domains during apoptosis: the unfolding of a deadly plot.

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