Ran-GTP regulates kinetochore attachment in somatic cells.

Arnaoutov A; Dasso M

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Ran-GTP regulates kinetochore attachment in somatic cells.

机译：Ran-GTP调节体细胞中的线粒体附着。

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The Ran GTPase controls multiple mitotic processes in Xenopus egg extracts, including mitotic checkpoints, spindle assembly and post-mitotic nuclear envelope reassembly. We have analyzed Ran's role in somatic cells. We uncovered a novel mitotic role of Ran-GTP, involving the Crm1 nuclear export receptor. This pathway is an important mode of Ran-GTP function during mitosis in mammalian somatic cells, which mediates the recruitment of the RanGAP1/RanBP2 complex to kinetochores and maintains the microtubule-based fibers connecting kinetochores to spindle poles (k-fibers). Here we discuss potential implications of these findings for normal k-fiber assembly.

机译：Ran GTPase控制非洲爪蟾卵提取物中的多个有丝分裂过程，包括有丝分裂检查点，纺锤体组装和有丝分裂后核被膜重组。我们已经分析了冉在体细胞中的作用。我们发现了Ran-GTP的一种新的有丝分裂作用，涉及Crm1核出口受体。该途径是哺乳动物体细胞有丝分裂过程中Ran-GTP功能的重要模式，它介导RanGAP1 / RanBP2复合物募集到动植物，并维持基于微管的纤维将动植物连接到纺锤体极（k纤维）。在这里，我们讨论了这些发现对正常K纤维组装的潜在影响。

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《Cell cycle》 |2005年第9期|共5页
作者
Arnaoutov A; Dasso M;
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正文语种 eng
中图分类细胞生物学;
关键词
Kinetochores; ran GTP-Binding Protein; 染色粒;

机译：Kinetochores;ran GTP-Binding Protein;染色粒;

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1. Ran-GTP regulates kinetochore attachment in somatic cells. [J] . Arnaoutov A, Dasso M Cell cycle . 2005,第9期

机译：Ran-GTP调节体细胞中的线粒体附着。
2. The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores [J] . Kim Jae Hyeong, Shim Jaegal, Ji Min-Ju, Nature Communications . 2014,第Auga期

机译：凝缩蛋白成分NCAPG2通过将Polo样激酶1募集到动植物体内来调节微管-线粒体的附着
3. The condensin component NCAPG2 regulates microtubule–kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores [J] . Jae Hyeong Kim, Jaegal Shim, Min-Ju Ji, Nature Communications . 2014,第1期

机译：凝集素成分NCAPG2通过将Polo样激酶1募集到动植物体内来调节微管-动线粒的附着
4. REGULATING RADIATION QUALITY AND INTENSITY USING NARROW-BAND LEDSFOR OPTIMIZATION OF SOMATIC EMBRYOGENESIS [C] . Takanori Hoshino, Joel L. Cuello Annual International Meeting of the American Society of Agricultural and Biological Engineers . 2011

机译：使用窄带LEDS进行调节辐射质量和强度，用于优化体细胞胚胎发生
5. Drosophila Cyclin J and the somatic pirna pathway cooperate to regulate germline stem cells. [D] . Albosta, Paul Michael. 2015

机译：果蝇细胞周期蛋白J和体细胞pirna途径合作调节种系干细胞。
6. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle [O] . 1994

机译：脊椎动物体细胞后期发育受一个检查点控制该检查点监测姐妹动线粒体附着在纺锤体上
7. Ran-GTP regulates Kinetochore Attachment in Somatic Cells [O] . Alexei Arnaoutov, Mary Dasso 2005

机译：RAN-GTP调节体细胞中的KINETOCHORE附件

Ran-GTP regulates kinetochore attachment in somatic cells.

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