How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA

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How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA

机译：错配修复酶如何平衡有效病变处理和对未受损DNA的最小作用的需求

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The DNA base excision repair (BER) pathway is required for maintaining genomic integrity and has recently been implicated in active DNA demethylation, revealing a key role in epigenetic gene regulation. To initiate BER, DNA glyco-sylases remove damaged or enzymatically modified bases by cleaving the base-sugar or .N-glycosylic bond, and the resulting abasic site is replaced by the appropriate nucleotide via downstream BER proteins. Thymine DNA glycosylase (TDG) plays an essential role in DNA repair and tran-scriptional regulation, by excising oxidized and/or deaminated forms of 5-methylcy-tosine (mC) that arise at CpG sites. TDG was discovered as an enzyme that excises thymine from G-T mispairs, mutagenic lesions that can arise by deamination of mC, and subsequent studies showed that TDG can excise a broad range of pyrimi-dine bases from DNA in vitro. It was recently discovered that TDG removes 5-formylcytosine (fC) and 5-carboxylcy-tosine (caC), oxidized forms of mC generated by Tet (ten-eleven translocation) enzymes.

机译：DNA碱基切除修复（BER）通路是维持基因组完整性所必需的，并且最近与主动DNA脱甲基有关，揭示了表观遗传基因调控中的关键作用。为了启动BER，DNA糖基化酶通过切割碱基糖或.N-糖基键来去除受损的或酶促修饰的碱基，然后通过下游BER蛋白将所得的脱碱基位点替换为适当的核苷酸。胸腺嘧啶DNA糖基化酶（TDG）通过切除CpG位点上产生的5-甲基半胱氨酸（mC）的氧化和/或脱氨基形式，在DNA修复和转录调控中起着至关重要的作用。 TDG被发现是一种酶，可从G-T错配中除去胸腺嘧啶，G-T错配是由mC脱氨而引起的致突变性损伤，随后的研究表明TDG可以在体外从DNA中除去广泛的嘧啶碱基。最近发现，TDG可以去除5-甲酰基胞嘧啶（fC）和5-羧基-胞嘧啶（caC），这是由Tet（十一种十一易位）酶产生的mC的氧化形式。

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《Cell cycle》 |2012年第18期|共2页
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中图分类细胞生物学;
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1. How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA [J] . Cell cycle . 2012,第18期

机译：错配修复酶如何平衡有效病变处理和对未受损DNA的最小作用的需求
2. Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway [J] . Grippon Seden, Zhao Qiyuan, Robinson Tom, Nucleic Acids Research . 2011,第7期

机译：大肠杆菌错配的尿嘧啶DNA糖基化酶与DNA结合的差异模式：对基础切除修复途径中的无基础病变加工和酶沟通的影响
3. Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway [J] . Christopher Dunsby, Geoff S. Baldwin, Gordon Kennedy, Nucleic acids research . 2011,第7期

机译：大肠杆菌错配的尿嘧啶DNA糖基化酶与DNA结合的差异模式：对基础切除修复途径中无基础性病变处理和酶沟通的影响
4. The Effect of Hydration on the Radiation Induction of DNA Base Lesions Processed by Base Excision Repair Enzymes [C] . Akinari Yokoya, Siobhan Cunniffe, Peter ONeill Workshop on Recognition of DNA Damage as Onset of Successful Repair: Computational and Experimental Approaches, Dec 18-19, 2001, Tokai . 2001

机译：水合对碱基切除修复酶处理的DNA碱基损伤辐射诱导的影响
5. Coupling of ATPase and mismatch recognition activities at the initiation of DNA mismatch repair. [D] . Antony, Edwin. 2005

机译：DNA错配修复开始时，ATPase和错配识别活性的耦合。
6. How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA [O] . Alexander C. Drohat, Edwin Pozharski, Atanu Maiti 2012

机译：错配修复酶如何平衡有效病变处理和对未受损DNA的最小作用的需求
7. Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway [O] . Grippon, Seden, Zhao, Qiyuan, Robinson, Tom, 2010

机译：大肠杆菌错配的尿嘧啶DNA糖基化酶与DNA结合的差异模式：对基础切除修复途径中无基础性病变处理和酶沟通的影响

How a mismatch repair enzyme balances the needs for efficient lesion processing and minimal action on undamaged DNA

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