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Dual roles of topoisomerase II

机译:拓扑异构酶II的双重作用

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摘要

Accurate chromosome segregation during mitosis is essential for the maintenance of genomic stability. An important event prior to mitotic entry is the decatenation of sister chromatids, which are highly entangled as a consequence of DNA replication. The decatenation checkpoint monitors the status of chromosome decatenation and delays entry into mitosis until the chromosomes have been sufficiently disentangled. This special feature of Cell Cycle highlights recent advances in our understanding of the biology and significance of the decatenation checkpoint
机译:有丝分裂期间正确的染色体分离对于维持基因组稳定性至关重要。有丝分裂进入之前的重要事件是姊妹染色单体的脱级,其由于DNA复制而高度纠缠。分离检查点监视染色体分离的状态,并延迟进入有丝分裂的时间,直到染色体充分解开为止。细胞周期的这一特殊功能突显了我们对脱位检查点生物学和意义的了解方面的最新进展

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