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首页> 外文期刊>Respiratory physiology & neurobiology >Micro and nanoparticle deposition in human nasal passage pre and post virtual maxillary sinus endoscopic surgery
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Micro and nanoparticle deposition in human nasal passage pre and post virtual maxillary sinus endoscopic surgery

机译：虚拟上颌窦内窥镜手术前后人鼻道中的微粒和纳米颗粒沉积

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Realistic 3-D models of the human nasal passages were developed pre and post virtual uncinectomy and Middle Meatal Antrostomy. A 3-D computational domain was constructed by a series of coronal CT scan images from a healthy subject. Then a virtual uncinectomy intervention and maxillary antrostomy were performed on the left nasal passage by removing the uncinate process and exposing the maxillary sinus antrum. For several breathing rates corresponding to low or moderate activities, the airflows in the nasal passages were simulated numerically pre and post virtual routine maxillary sinus endoscopic surgery. The airflow distribution in the nasal airway, maxillary and frontal sinuses were analyzed and compared between pre and post surgery cases. A Lagrangian trajectory analysis approach was used for evaluating the path and deposition of microparticles in the nasal passages and maxillary sinuses. A diffusion model was used for nanoparticle transport and deposition analysis. The deposition rate of the inhaled micro and nanoparticles in the sinuses were evaluated and compared for pre and post operation conditions. The results showed that after maxillary sinus endoscopic surgery, the inhaled nano and microparticles can easily enter this sinus due to penetration of the airflow into the sinus cavity. This was in contrast to the preoperative condition in which almost no particles entered the sinuses. These results could be of importance for a better understanding of the effect of sinus endoscopic surgery on patient exposure to particulate pollution and inhalation drug delivery. The significantly higher airflow rate and particle deposition in the sinus could be a reason for the discomfort reported by some patient after maxillary sinus endoscopic surgery.
机译：在虚拟非癌切除术和中位肉牛吻合术之前和之后开发了逼真的人鼻通道3-D模型。通过一系列来自健康受试者的冠状CT扫描图像构建了3-D计算域。然后，通过去除结突并暴露上颌窦窦，对左侧鼻腔进行虚拟的癌切除术干预和上颌窦吻合术。对于对应于低度或中度活动的几种呼吸速率，在虚拟常规上颌窦内窥镜手术前后对鼻道中的气流进行数值模拟。分析并比较了术前和术后病例的鼻气道，上颌窦和额窦的气流分布。拉格朗日轨迹分析方法用于评估鼻腔通道和上颌窦中微粒的路径和沉积。扩散模型用于纳米颗粒的运输和沉积分析。评估鼻窦中吸入的微粒和纳米颗粒的沉积速率，并比较术前和术后条件。结果显示，在上颌窦内窥镜手术后，由于气流渗透到窦腔中，吸入的纳米颗粒和微粒很容易进入该窦。这与术前几乎没有颗粒进入鼻窦的情况形成对比。这些结果对于更好地了解鼻窦内窥镜手术对患者暴露于颗粒物污染和吸入药物输送的影响可能具有重要意义。上颌窦内窥镜手术后，部分患者报告不适感的原因可能是窦内明显更高的气流速率和颗粒沉积。

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