Comparison of PNA clamping and direct sequencing for detecting KRAS mutations in matched tumour tissue, cell block, pleural effusion and serum from patients with malignant pleural effusion

Kang Ji Young; Park Chan Kwon; Yeo Chang Dong; Lee Hea Yeon; Rhee Chin Kook; Kim Seung Joon; Kim Seok Chan; Kim Young Kyoon; Park Mi Sun; Yim Hyeon Woo

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Comparison of PNA clamping and direct sequencing for detecting KRAS mutations in matched tumour tissue, cell block, pleural effusion and serum from patients with malignant pleural effusion

机译：PNA钳夹法和直接测序法在恶性胸腔积液患者匹配的肿瘤组织，细胞块，胸腔积液和血清中检测KRAS突变的比较

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Background and objectivePeptide nucleic acid (PNA)-mediated real-time polymerase chain reaction clamping was recently developed to improve mutation detection sensitivity. Pleural effusion could be a good sample candidate for mutation analysis. To establish if PNA clamping could be used to detect KRAS mutation in particular in pleural effusion, we analysed its diagnostic performance.

机译：背景和目的最近开发了肽核酸（PNA）介导的实时聚合酶链反应钳制技术，以提高突变检测的敏感性。胸腔积液可能是进行突变分析的良好样本。为了确定PNA钳制是否可以用于检测KRAS突变，特别是在胸腔积液中，我们分析了其诊断性能。

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《Respirology :》 |2015年第1期|共9页
作者
Kang Ji Young; Park Chan Kwon; Yeo Chang Dong; Lee Hea Yeon; Rhee Chin Kook; Kim Seung Joon; Kim Seok Chan; Kim Young Kyoon; Park Mi Sun; Yim Hyeon Woo;
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正文语种 eng
中图分类呼吸系及胸部疾病;
关键词
direct sequencing; Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation; malignant pleural effusion; peptide nucleic acid-mediated real-time PCR clamping;

机译：直接测序;克尔斯滕大鼠肉瘤病毒癌基因同源物（KRAS）突变;恶性胸腔积液;肽核酸介导的实时PCR钳制;

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1. Comparison of PNA clamping and direct sequencing for detecting KRAS mutations in matched tumour tissue, cell block, pleural effusion and serum from patients with malignant pleural effusion [J] . Kang Ji Young, Park Chan Kwon, Yeo Chang Dong, Respirology : . 2015,第1期

机译：PNA钳夹法和直接测序法在恶性胸腔积液患者匹配的肿瘤组织，细胞块，胸腔积液和血清中检测KRAS突变的比较
2. Comparison of PNA Clamping-assisted Fluorescence Melting Curve Analysis and PNA Clamping in Detecting EGFR Mutations in Matched Tumor Tissue, Cell Block, Pleural Effusion and Blood of Lung Cancer Patients With Malignant Pleural Effusion [J] . SANG HOON JEON, HYUNG WOO KIM, BIT NA KIM, In vivo. . 2019,第2期

机译：PNA钳夹辅助荧光熔解曲线分析与PNA钳夹对肺癌患者恶性胸腔积液匹配肿瘤组织，细胞阻滞，胸腔积液和血液中EGFR突变检测的比较
3. P1.01-076 Comparison of PANA Mutyper and PNA Clamping for Detecting KRAS Mutations in Tumor Tissue, Cell Block and Pleural Effusion from Cancer [J] . C.K. Park, S.J. Kim, Y.K. Kim Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer . 2017,第11期

机译：P1.01-076 PANA蛋白和PNNA钳位的比较检测肿瘤组织中KRAS突变，细胞块和癌症胸腔积液
4. Detection of malignant pleural effusion based on features of cell [C] . Zhiyong Gao, Xiangming Liu, Tonghan Lan International Symposium on Interdisciplinary Life Sciences: From Genome to Function . 2005

机译：基于细胞特征的恶性胸腔积液检测
5. Comparison of PNA Clamping-assisted Fluorescence Melting Curve Analysis and PNA Clamping in Detecting EGFR Mutations in Matched Tumor Tissue Cell Block Pleural Effusion and Blood of Lung Cancer Patients With Malignant Pleural Effusion [O] . SANG HOON JEON, HYUNG WOO KIM, BIT NA KIM, 2019

机译：PNA钳夹辅助荧光熔解曲线分析与PNA钳夹对肺癌患者恶性胸腔积液匹配肿瘤组织细胞阻滞胸腔积液和血液中EGFR突变检测的比较
6. Comparison of PNA Clamping-assisted Fluorescence Melting Curve Analysis and PNA Clamping in Detecting EGFR Mutations in Matched Tumor Tissue, Cell Block, Pleural Effusion and Blood of Lung Cancer Patients With Malignant Pleural Effusion [O] . SANG HOON JEON, HYUNG WOO KIM, BIT NA KIM, 2019

机译：PNA钳位辅助荧光熔化曲线分析和PATPN突变检测肿瘤组织，细胞块，胸腔积液和恶性胸腔积液性肺癌患者血液损伤的比较

Comparison of PNA clamping and direct sequencing for detecting KRAS mutations in matched tumour tissue, cell block, pleural effusion and serum from patients with malignant pleural effusion

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