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首页> 外文期刊>Respirology : >Reduced lung uptake of iodine-123 metaiodobenzylguanidine in high-altitude pulmonary oedema.
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Reduced lung uptake of iodine-123 metaiodobenzylguanidine in high-altitude pulmonary oedema.

机译：在高海拔肺水肿中减少了碘123碘碘苄基胍对肺的吸收。

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BACKGROUND AND OBJECTIVE: Iodine-123 metaiodobenzylguanidine ((123)I-MIBG) uptake in the lungs is a potentially suitable marker of pulmonary endothelial function because MIBG behaviour in the pulmonary circulation is quantitatively similar to that of norepinephrine. In addition, hypoxia reduces (123)I-MIBG transport in pulmonary endothelial cells in vitro. The present study was undertaken to evaluate (123)I-MIBG uptake in the lungs of patients with high-altitude pulmonary oedema (HAPE). METHODS: (123)I-MIBG scintigraphy was performed in eight patients with HAPE. The findings were compared with those in 24 patients with congestive heart failure due to idiopathic dilated cardiomyopathy (DCM) and in 13 normal control subjects. In patients with HAPE, the (123)I-MIBG examination was performed 7-14 days after admission. Anterior planar images were acquired 15 min after injection of (123)I-MIBG and the total lung to upper mediastinum ratio (L/M ratio) was calculated for both lungs. RESULTS: The L/M ratio in patients with HAPE (1.39 +/- 0.15, mean +/- SD) was significantly lower than in those with congestive heart failure/DCM (1.66 +/- 0.16) or in normal controls (1.53 +/- 0.14). There were no significant differences among the groups in (123)I-MIBG accumulation in the heart. CONCLUSIONS: Although the mechanism of altered (123)I-MIBG kinetics in HAPE remains obscure, decreased (123)I-MIBG uptake in the lungs may potentially be a suitable technique for the assessment of pathological conditions associated with the pulmonary endothelium.
机译：背景和目的：肺中碘-123碘碘苄基胍（（123）I-MIBG）的摄取是肺内皮功能的潜在合适标志，因为肺循环中的MIBG行为在数量上与去甲肾上腺素相似。另外，低氧降低了体外肺内皮细胞中的（123）I-MIBG转运。本研究旨在评估高海拔肺水肿（HAPE）患者肺中的（123）I-MIBG摄取。方法：对8例HAPE患者进行了（123）I-MIBG闪烁显像。将研究结果与24例因特发性扩张型心肌病（DCM）导致的充血性心力衰竭患者和13例正常对照者进行了比较。对于HAPE患者，入院后7-14天进行（123）I-MIBG检查。注射（123）I-MIBG 15分钟后获取前平面图像，并计算两个肺的总肺对上纵隔比率（L / M比率）。结果：HAPE患者的L / M比（1.39 +/- 0.15，平均+/- SD）显着低于充血性心力衰竭/ DCM（1.66 +/- 0.16）或正常对照组（1.53 + /-0.14）。心脏中的（123）I-MIBG蓄积在各组之间没有显着差异。结论：尽管HAPE中改变（123）I-MIBG动力学的机制仍然不清楚，但是降低肺中（123）I-MIBG的摄取可能是评估与肺内皮相关的病理状况的合适技术。

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