...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Respirology : >Cross-sectional and longitudinal construct validity of the Saint George's Respiratory Questionnaire in patients with IPF.
【24h】

Cross-sectional and longitudinal construct validity of the Saint George's Respiratory Questionnaire in patients with IPF.

机译：IPF患者圣乔治呼吸问卷的横截面和纵向结构有效性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND OBJECTIVE: This study was performed to confirm the cross-sectional and longitudinal construct validity of the Saint George's Respiratory Questionnaire (SGRQ) for the measurement of health-related quality of life (HRQoL) in patients with IPF. METHODS: Sixty-eight patients with IPF responded to the SGRQ and pulmonary function tests (PFT), dyspnoea testing, arterial blood gas analysis, 6-min walk tests (6MWT) and high-resolution computed tomography were performed in a baseline study. A follow-up study was performed on 45 of these patients. RESULTS: In the baseline study HRQoL as measured by the SGRQ was substantially impaired in IPF patients, especially in symptoms and activity domains. A significant decline in HRQoL was observed in the activity domain during follow up. TLC and changes in TLC showed the most significant inverse correlations with each SGRQ domain (r < -0.3, P < 0.05). In a stepwise multiple regression analysis, TLC contributed most significantly to each SGRQ component baseline score. Similar results were also observed during follow up. There was a significant correlation between total CT scores and each component of the SGRQ (r > 0.3, P < or = 0.001). Changes in ground-glass opacity on CT (CT-alv) were also correlated with changes in each SGRQ domain (r > 0.3, P < or = 0.001). Stepwise multiple regression analysis showed that interstitial opacity on CT (CT-fib) contributed to variation in the baseline activity score, and that changes in CT-alv independently contributed to overall changes in the SGRQ domains during follow up. The dyspnoea score, and changes in the dyspnoea score, correlated significantly with the SGRQ sores, with the exception of the symptoms score, in both the baseline and follow-up studies. CONCLUSIONS: HRQoL as assessed by the SGRQ showed good cross-sectional and longitudinal construct validity in patients with IPF. However, additional studies are required to analyse the reliability and responsiveness so that the SGRQ can be used in patients with IPF.
机译：背景与目的：本研究旨在确认圣乔治呼吸问卷（SGRQ）在IPF患者健康相关生活质量（HRQoL）测量中的横断面和纵向结构有效性。方法：在基线研究中，对68名IPF患者进行了SGRQ和肺功能测试（PFT），呼吸困难测试，动脉血气分析，6分钟步行测试（6MWT）和高分辨率计算机断层扫描。对其中45位患者进行了随访研究。结果：在基线研究中，由SGRQ测量的HRQoL在IPF患者中明显受损，尤其是在症状和活动领域。在随访期间，在活动域中观察到HRQoL显着下降。 TLC和TLC的变化显示出与每个SGRQ域最显着的负相关（r <-0.3，P <0.05）。在逐步多元回归分析中，TLC对每个SGRQ组件基线得分的贡献最大。在随访期间也观察到类似结果。总CT评分与SGRQ的每个组成部分之间存在显着相关性（r> 0.3，P <或= 0.001）。 CT（CT-alv）上的毛玻璃不透明度的变化也与每个SGRQ域的变化相关（r> 0.3，P <或= 0.001）。逐步多元回归分析表明，CT上的组织间隙不透明（CT-fib）导致基线活动评分的变化，而随访期间CT-alv的变化独立地影响了SGRQ域的总体变化。在基线研究和随访研究中，除了症状评分外，呼吸困难评分和呼吸困难评分的变化与SGRQ疮明显相关。结论：SGRQ评估的HRQoL在IPF患者中显示出良好的横截面和纵向结构有效性。但是，还需要进行其他研究来分析其可靠性和响应性，以便SGRQ可以用于IPF患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号