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Asthma Control Test correlates well with the treatment decisions made by asthma specialists.

机译：哮喘控制测试与哮喘专家做出的治疗决策密切相关。

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BACKGROUND AND OBJECTIVE: Poor assessment of asthma control results in suboptimal treatment. Identifying parameters that accurately assess control will benefit treatment decisions. The Asthma Control Test (ACT) is a five-item questionnaire for the assessment of asthma control. This study evaluated its correlation with the treatment decisions made by asthma specialists in an outpatient clinic setting, and compared its performance with other conventional parameters including spirometry, PEF rate (PEFR), fractional exhaled nitric oxide (FeNO) and BHR. METHODS: The 383 (122 men) study subjects completed a 1-month diary on symptoms and PEFR before the assessment. All subjects then completed the ACT together with same-day spirometry and FeNO measurement. BHR to methacholine was performed in 73 subjects in the week before assessment. Asthma specialists, blinded to the results of the ACT, FeNO and BHR (but not spirometry and PEFR), assessed the patients' level of control according to the 2006 version of the Global Initiative for Asthma guidelines and made appropriate treatment decision. RESULTS: The group mean (SD) age was 46.1 (13.4) years with pre-bronchodilator FEV(1) 84.72 (20.81) % predicted. Receiver operating characteristic (ROC) curve analysis found that an ACT score of < or = 20 best correlated with uncontrolled asthma (area under curve (AUC) = 0.76) with a sensitivity of 70.5%, specificity 76.0%, positive predictive value 76.2% and negative predictive value 70.2% for predicting step-up of asthma therapy. On ROC analysis, the ACT score had the highest AUC (0.81 (P < 0.001)) for changing asthma therapy when compared with FeNO, spirometry, PEFR and BHR parameters CONCLUSIONS: The ACT correlated better with treatment decisions made by asthma specialists than spirometry, PEFR and FeNO.
机译：背景与目的：对哮喘控制的评估不佳导致治疗效果欠佳。确定准确评估控制的参数将有利于治疗决策。哮喘控制测试（ACT）是用于评估哮喘控制的五项问卷。这项研究评估了其与门诊诊所环境中哮喘专家做出的治疗决定的相关性，并将其性能与其他常规参数进行了比较，包括肺活量测定，PEF率（PEFR），呼出一氧化氮（FeNO）和BHR。方法：383名（122名男性）研究对象在评估前完成了有关症状和PEFR的1个月日记。然后，所有受试者都完成了ACT，并进行了当天的肺活量测定和FeNO测量。评估前一周，对73名受试者进行了甲乙胆碱的BHR试验。哮喘专家对ACT，FeNO和BHR（但不是肺活量测定法和PEFR）的结果视而不见，根据2006年版《全球哮喘倡议》指南评估了患者的控制水平，并做出了适当的治疗决策。结果：组平均（SD）年龄为46.1（13.4）岁，预计支气管扩张剂前FEV（1）为84.72（20.81）％。接受者操作特征（ROC）曲线分析发现ACT得分<或= 20与不受控制的哮喘（曲线下面积（AUC）= 0.76）最佳相关，敏感性为70.5％，特异性为76.0％，阳性预测值为76.2％，预测哮喘治疗逐步上升的阴性预测值为70.2％。在ROC分析中，与FeNO，肺活量测定法，PEFR和BHR参数相比，改变哮喘治疗的ACT评分具有最高的AUC（0.81（P <0.001））结论：与哮喘专家相比，ACT与哮喘专家做出的治疗决策相关性更高， PEFR和FeNO。

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