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首页> 外文期刊>Respirology : >Correlation of C-reactive protein with disease severity in CT diagnosed emphysema.
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Correlation of C-reactive protein with disease severity in CT diagnosed emphysema.

机译：CT诊断的肺气肿中C反应蛋白与疾病严重程度的相关性。

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BACKGROUND AND OBJECTIVE: Recent studies suggest that CRP levels are related to airflow obstruction. However, limited data exist on the relevance of CRP levels in individuals with or without emphysema. The aim of this study was to assess the relationship between the extent of emphysema, COPD severity and serum CRP levels. METHODS: Lung function tests and high-sensitivity CRP were examined in 651 males with stable disease who underwent CT screening for lung cancer. CRP levels were examined cross-sectionally in individuals with various degrees of emphysema and in those without emphysema. RESULTS: Emphysema was detected in 179 (34.7%) of 516 current smokers. Airflow obstruction was observed in 47 (28.8%) of 163 smokers with mild emphysema, in eight (57.1%) of 14 smokers with moderate emphysema, and in two of two individuals with severe emphysema. CRP levels were not higher in individuals with mild or moderate emphysema compared with individuals without emphysema. Among 98 individuals with airflow obstruction (19.0% of the 516 current smokers), there was a modest correlation between CRP levels and FEV(1)%. CONCLUSIONS: The severity of COPD varied in individuals with similar degrees of emphysema. CRP levels were not significantly higher in individuals with mild or moderate emphysema compared with individuals without emphysema but CRP levels were modestly correlated with FEV(1)% among individuals with airflow obstruction.
机译：背景与目的：最近的研究表明，CRP水平与气流阻塞有关。但是，关于有或没有肺气肿的个体中CRP水平相关性的数据有限。这项研究的目的是评估肺气肿程度，COPD严重程度和血清CRP水平之间的关系。方法：对651例经过CT检查的稳定疾病男性进行了肺功能检查和高敏CRP检查。在患有不同程度的肺气肿的个体和没有肺气肿的个体中，横断面检查CRP水平。结果：516名当前吸烟者中有179名（34.7％）检出肺气肿。在163名轻度肺气肿吸烟者中有47名（28.8％）出现气流阻塞，在14名中度肺气肿吸烟者中有8名（57.1％）出现了严重的肺气肿。轻度或中度肺气肿患者的CRP水平不高于无肺气肿患者。在98位有气流阻塞的个体中（目前516名吸烟者中的19.0％），CRP水平与FEV（1）％之间存在适度的相关性。结论：肺气肿程度相似的个体COPD的严重程度各不相同。与轻度或中度肺气肿患者相比，CRP水平没有明显升高，但在有气流阻塞的患者中，CRP水平与FEV（1）％的相关性中等。

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