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首页> 外文期刊>Resuscitation. >Resuscitation from experimental heatstroke by brain cooling therapy.
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Resuscitation from experimental heatstroke by brain cooling therapy.

机译：通过脑部冷却疗法从实验性中暑中复苏。

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We have used hypothermic retrograde jugular venous flush to cool the brain previously and to provide better resuscitation than peripheral cold saline infusion during heatstroke in the rat. The current study was performed to assess the effects of brain cooling further on production of reactive nitrogen species, reactive oxygen species, tumor necrosis factor-alpha, and interleukin-10 in both serum and brain during heatstroke. Rats, under general anaesthesia, were randomized into the following groups and given: (a) 36 degrees C or (b) 4 degrees C saline infusion in the external jugular vein immediately after onset of heatstroke. They were exposed to an ambient temperature of 43 degrees C for exactly 70 min to induce heatstroke. When the 36 degrees C saline-treated rats underwent heat stress, their survival time values were found to be 21-25 min. Immediately after the onset of heatstroke, resuscitation with an i.v. dose of 4 degrees C saline greatly improved survival (226-268 min). Compared with the normothermic controls, the 36 degrees C saline-treated heatstroke rats displayed higher levels of brain temperature, intracranial pressure, serum and hypothalamic nitric oxide metabolite, tumor necrosis factor-alpha and dihydroxybenzoic acid as well as hypothalamic inducible nitric oxide synthase immunoreactivity. In contrast, the values of mean arterial pressure, cerebral perfusion pressure, and hypothalamic levels of local blood flow, and partial pressure of oxygen were all significantly lower during heatstroke. The cerebrovascular dysfunction, the increased levels of nitric oxide metabolites, tumor necrosis factor-alpha, and dihydroxybenzoic acid in both the serum and the hypothalamus, and the increased levels of hypothalamic inducible nitric oxide synthase immunoreactivity occurred during heatstroke were significantly suppressed by brain cooling. Although the serum and hypothalamic interleukin-10 maintained at a negligible level before stress, they were significantly elevated by brain cooling during heatstroke. These findings suggest that brain cooling may resuscitate persons who had heatstroke by decreasing overproduction of reactive nitrogen species, tumor necrosis factor-alpha, reactive oxygen species and cerebrovascular dysfunction, but increasing production of interleukin-10.
机译：我们已经使用低温逆行颈静脉冲洗术来冷却大脑，并且比大鼠中暑期间的外周冷盐水输注提供了更好的复苏。进行本研究的目的是评估中暑时脑部冷却对血清和脑中活性氮，活性氧，肿瘤坏死因子-α和白介素10产生的影响。在全身麻醉下，将大鼠随机分为以下几组并给予：（a）中暑后立即在颈外静脉内输注36摄氏度或（b）4摄氏度盐水。将它们暴露在43摄氏度的环境温度下70分钟以引起中暑。当36摄氏度盐水处理的大鼠遭受热应激时，发现其存活时间值为21-25分钟。中暑发作后，立即进行静脉复苏。剂量为4℃的生理盐水可大大提高生存期（226-268分钟）。与正常体温对照组相比，在36°C盐水处理的中暑大鼠表现出更高的脑温，颅内压，血清和下丘脑一氧化氮代谢产物，肿瘤坏死因子-α和二羟基苯甲酸以及下丘脑诱导的一氧化氮合酶免疫反应性。相反，中暑期间的平均动脉压，脑灌注压和下丘脑局部血流水平以及氧气分压值均显着降低。脑冷却可显着抑制中暑时发生的脑血管功能障碍，血清和下丘脑中一氧化氮代谢产物，肿瘤坏死因子-α和二羟基苯甲酸的升高以及下丘脑诱导型一氧化氮合酶免疫反应性的升高。尽管在应激前血清和下丘脑白细胞介素10维持在可以忽略的水平，但在中暑期间由于脑部冷却而明显升高。这些发现表明，脑部冷却可以通过减少活性氮，肿瘤坏死因子-α，活性氧和脑血管功能障碍的过量产生，但增加白细胞介素10的产生来使中暑的人复苏。

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