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Herpes simplex virus gene products: the accessories reflect her lifestyle well.

机译：单纯疱疹病毒基因产品：配件很好地反映了她的生活方式。

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摘要

Herpes simplex virus (HSV) genomic DNA contains at least 74 distinct genes. A set of 40 genes, termed the 'core genes', is commonly found in all herpesviruses; their products include four capsid proteins, six DNA replication proteins, seven DNA packaging/cleavage proteins, four envelope glycoproteins, as well as several others. Although approximately half of the HSV genes are not essential for replication in cell cultures, all accessory gene products are predicted to play indispensable roles for viral replication and dissemination in vivo. Intensive studies have been undertaken to elucidate the functions and roles of HSV gene products, and we are now able to address, at least partially, the biological aspects of all HSV encoded proteins. This article is a brief summary of our present knowledge of the functions and roles of HSV gene products with special attention focused on UL14, UL34, UL51, UL56 and US3, all of which are thought to be involved in HSV egress. Furthermore, efforts are discussed to generate replication-competent HSV lacking a single or multiple accessory gene(s) for potential use in gene therapy or as anti-cancer therapeutics. Finally, specific HSV gene products are being explored as therapeutic agents.
机译：单纯疱疹病毒（HSV）基因组DNA至少包含74个不同的基因。在所有疱疹病毒中通常会发现一组40个基因，称为“核心基因”。他们的产品包括四种衣壳蛋白，六个DNA复制蛋白，七个DNA包装/切割蛋白，四个包膜糖蛋白，以及其他几种。尽管大约一半的HSV基因对于细胞培养中的复制不是必需的，但据预测，所有辅助基因产物都将在体内病毒复制和传播中发挥不可或缺的作用。已经进行了深入的研究以阐明HSV基因产物的功能和作用，并且我们现在能够至少部分地解决所有HSV编码蛋白的生物学方面的问题。本文是对我们目前对HSV基因产物的功能和作用的认识的简要总结，特别关注UL14，UL34，UL51，UL56和US3，这些都被认为与HSV的释放有关。此外，讨论了产生具有复制能力的HSV的努力，所述HSV缺乏单个或多个辅助基因，可潜在地用于基因治疗或用作抗癌治疗剂。最后，正在探索特定的HSV基因产物作为治疗剂。

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