• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Rhinology >Intracellular residency is frequently associated with recurrent Staphylococcus aureus rhinosinusitis.
【24h】

Intracellular residency is frequently associated with recurrent Staphylococcus aureus rhinosinusitis.

机译：细胞内驻留常与复发性金黄色葡萄球菌鼻窦炎相关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: The prevalence of intracellular Staphylococcus aureus organisms in the nasal mucosa of patients with recurrent infectious rhinosinusitis episodes was studied. METHOD: Twenty-seven consecutive adult patients who failed medical management of chronic rhinosinusitis (CRS) of multiple origins, associated or not with nasal polyposis, were consecutively enrolled for endonasal sinus surgery (including partial middle turbinectomy, middle antrostomy, ethmoidectomy, sphenoidotomy) and followed for a 12-month post-operative period. RESULTS: Seventeen of these patients showed the presence of intracellular S. aureus as detected by confocal laser scan immunofluorescence microscopy in epithelial cells of surgical intranasal biopsy specimens. Nine of the patients with and two without intracellular bacteria yielded S. aureus in endoscopically guided cultures of middle meatus secretions, despite the recent administration of prophylactic antibiotics. Eleven of the 17 patients with intracellular S. aureus relapsed forrhinosinusitis within the 12-month follow-up period. Molecular typing of sequential S. aureus isolates demonstrated the persistence of unique patient-specific S. aureus clonotypes in nine of the patients with intracellular bacteria during the 12-month follow-up. CONCLUSION: The presence of intracellular S. aureus in epithelial cells of the nasal mucosa is a significant risk factor for recurrent episodes of rhinosinusitis due to persistent bacterial clonotypes, which appear refractory to antimicrobial and surgical therapy.
机译：目的：研究复发性传染性鼻－鼻窦炎发作患者鼻黏膜中细胞内金黄色葡萄球菌的流行情况。方法：连续入选27例因多源性慢性鼻-鼻窦炎（CRS）药物治疗失败而与鼻息肉相关或不相关的成年患者，进行鼻内鼻窦手术（包括部分中端肾小管切开术，中位吻合术，筛窦切除术，蝶窦切开术）和术后为期12个月。结果：通过共聚焦激光扫描免疫荧光显微镜在鼻腔手术活检标本的上皮细胞中检测到这些患者中有十七例存在金黄色葡萄球菌。尽管最近使用了预防性抗生素，但在有鼻内分泌物的内窥镜引导培养中，有9个有细胞内细菌的患者和2个没有细胞内细菌的患者产生了金黄色葡萄球菌。 17例细胞内金黄色葡萄球菌患者中有11例在12个月的随访期内复发了鼻窦炎。连续金黄色葡萄球菌分离株的分子分型显示在12个月的随访期间，在9名细胞内细菌患者中，独特的患者特异性金黄色葡萄球菌克隆型持续存在。结论：鼻黏膜上皮细胞中存在细胞内金黄色葡萄球菌是持续存在的细菌克隆型导致鼻-鼻窦炎复发发作的重要危险因素，这种类型对抗菌和外科治疗不利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号