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Isoform diversity and modulation of sodium channels by protein kinases.

机译:蛋白激酶对亚型的多样性和钠通道的调节。

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摘要

Although voltage-dependent sodium channels from the brain have been realized as targets for regulatory protein phosphorylation since the first isolation of sodium channels as proteins, the functional role of phosphoprotein formation has been obscured until recently. The review summarizes progress on the modulation of voltage-dependent sodium channels by serine/threonine protein kinases, i.e. PKA and PKC. Divergent modulation is discussed in context with divergent primary structure of the alpha-subunit. Copyright Copyright 1999 S. Karger AG, Basel
机译:尽管自从钠通道作为蛋白质的首次分离以来,来自大脑的电压依赖性钠通道已被实现为调节蛋白磷酸化的靶标,但直到最近为止,磷蛋白形成的功能作用仍被掩盖。该综述总结了丝氨酸/苏氨酸蛋白激酶,即PKA和PKC在电压依赖性钠通道的调节方面的进展。在与α-亚基的发散一级结构的上下文中讨论发散调制。版权版权所有1999 S.Karger AG,巴塞尔

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