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Hepatocellular hydration: Signal transduction and functional implications [Review]

机译:肝细胞水化:信号转导及其功能意义[综述]

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In recent years it has become increasingly evident that cell volume represents a major determinant of cellular function in a variety of cell types. In mammalian cells, hydration may change dynamically in response to hormones, ethanol, anise-osmotic environments, oxidative stress or by cumulative substrate uptake. The aim of this review is to provide an outline of our current knowledge regarding the impact of cell volume on liver function. Special emphasis will be placed on the regulation of proteolysis and secretory pathways in hepatocytes. Furthermore, mechanisms implicated in sensing changes of hydration will be briefly discussed. Copyright (C) 2000 S. Karger AG Basel. [References: 78]
机译:近年来,越来越明显的是,细胞体积代表了多种细胞类型中细胞功能的主要决定因素。在哺乳动物细胞中,水合作用可能会随着激素,乙醇,茴香渗透环境,氧化应激或底物的累积吸收而动态变化。这篇综述的目的是概述我们目前有关细胞体积对肝功能的影响的知识。将特别强调对肝细胞中蛋白水解和分泌途径的调节。此外,将简要讨论与感测水合变化有关的机制。版权所有(C)2000 S.Karger AG Basel。 [参考:78]

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