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首页> 外文期刊>Rheumatic diseases clinics of North America >Animal models of myositis.
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Animal models of myositis.

机译：肌炎的动物模型。

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Current animal models of human myositis include spontaneous, induced, and transgenic models. Although it is clear that none of these models possesses all the features of the human diseases, they may provide insight into the pathophysiologic mechanisms, and possibly the therapy, of inflammatory muscle disease. Because the human IIMs are phenotypically heterogeneous, but may be divided into more homogeneous subgroups based upon clinical or serologic features, it is possible that different pathogeneses are involved in different subgroups. It is unlikely that any single model would reproduce all features of the human disease. It may be possible, however, to gain insight into some subgroups of the human disease if certain animal models faithfully reproduce one or more subtypes or aspects of the IIMs. Because immunogenetic risk factors, and exposure to certain environmental agents important in triggering myositis in genetically susceptible persons, may be necessary components for human disease induction, transgenic approaches to humanizing murine immune systems and a better understanding of environmental risk factors will be productive avenues for future research. Additional investigations into the molecular basis of the human myositis syndromes and the pathogenesis of the spontaneous, induced, and transgenic animal models should ultimately allow for better understanding and therapy of these diseases.
机译：当前的人类肌炎的动物模型包括自发，诱导和转基因模型。尽管很明显，这些模型都不具有人类疾病的所有特征，但是它们可以提供炎性肌肉疾病的病理生理机制以及治疗方法的见识。由于人IIM在表型上是异质的，但根据临床或血清学特征可分为更均一的亚组，因此不同的病原体可能会涉及不同的亚组。任何单一的模型都不可能复制人类疾病的所有特征。但是，如果某些动物模型忠实地复制IIM的一种或多种亚型或方面，则有可能深入了解人类疾病的某些亚组。由于免疫遗传风险因素以及对遗传易感人群触发肌炎重要的某些环境因素的暴露可能是人类疾病诱导的必要组成部分，因此使鼠类免疫系统人源化的转基因方法以及对环境风险因素的更好理解将是未来的生产途径研究。对人类肌炎综合征的分子基础以及自发，诱导和转基因动物模型的发病机理进行的其他研究最终应该可以使人们更好地了解和治疗这些疾病。

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