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首页> 外文期刊>Rhinology >No evidence for a correlation of Glutathione S-Tranferase polymorphisms and chronic rhinosinusitis.
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No evidence for a correlation of Glutathione S-Tranferase polymorphisms and chronic rhinosinusitis.

机译：没有证据表明谷胱甘肽S-转移酶多态性与慢性鼻-鼻窦炎相关。

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摘要

OBJECTIVE: Cellular detoxification mechanisms are mandatory for cellular protection against oxidative stress and reactive oxygen species. One major group of antioxidative active enzymes involved in cellular detoxification are the Glutathione S-Transferases (GST). Multiple subtypes like GSTM1, GSTP1, and GSTT1 and variants of them are known, arising from allelic variations of the GST loci. Moreover, functional variants occur in high percentages and have been associated with diseases like bronchial asthma and bronchial hyperresponsiveness. The interplay of oxidative stress, detoxifying genes like GSTs and the genesis of respiratory tract illness is under contradictory debate. In this study, we analysed the potential association of GST-polymorphisms and chronic rhinosinusitis (CRS). METHODS: In total 170 nasal tissue samples, 49 tissue samples from patients with CRS without nasal polyps, 69 tissue samples from CRS with nasal polyps and 52 healthy tissue controls of the inferior turbinate were analysed for their individual GST-status. Genotypes for GSTM1 (null versus present), GSTT1 (null versus present), and GSTP1 (Ile105Val) were determined by Polymerase Chain Reaction. The respective genotypes were correlated to the incidence of CRS with and without nasal polyps in aspirin-tolerant and intolerant patients and to the individual health status concerning asthma and allergies. RESULTS: No correlation between any GST-polymorphism and CRS with and without nasal polyps or allergies or asthma or aspirin-intolerance was observed. CONCLUSION: Our results do not suggest that there is a relevant genetic predisposition considering the individual GST-status for the susceptibility of nasal respiratory epithelia leading to CRS.
机译：目的：细胞排毒机制对于保护细胞免受氧化应激和活性氧的影响是必不可少的。参与细胞排毒的主要抗氧化活性酶是谷胱甘肽S-转移酶（GST）。由GST位点的等位基因变异引起的多个亚型，如GSTM1，GSTP1和GSTT1及其变体是已知的。此外，功能性变异以高百分比出现，并与诸如支气管哮喘和支气管高反应性等疾病相关。氧化应激，像GSTs这样的解毒基因与呼吸道疾病的发生之间的相互作用正处于矛盾的辩论之中。在这项研究中，我们分析了GST多态性与慢性鼻鼻窦炎（CRS）的潜在关联。方法：在总共170个鼻腔组织样本中，分析了49例无鼻息肉的CRS患者的组织样本，69例具有鼻息肉的CRS的组织样本和52个下鼻甲的健康组织对照的个体GST状态。通过聚合酶链反应确定GSTM1（无效与存在），GSTT1（无效与存在）和GSTP1（Ile105Val）的基因型。各自的基因型与阿司匹林耐受和不耐受患者鼻息肉伴或不伴鼻息肉的CRS发生率以及与哮喘和过敏相关的个体健康状况相关。结果：在有或没有鼻息肉或过敏，哮喘或阿司匹林耐受性的情况下，未发现任何GST多态性与CRS相关。结论：我们的结果并不表明考虑到个体GST状态对导致CRS的鼻呼吸道上皮易感性存在相关的遗传易感性。

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