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首页> 外文期刊>Rheumatology >Health-related quality of life of patients with juvenile idiopathic arthritis coming from 3 different geographic areas. The PRINTO multinational quality of life cohort study.
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Health-related quality of life of patients with juvenile idiopathic arthritis coming from 3 different geographic areas. The PRINTO multinational quality of life cohort study.

机译:来自3个不同地区的青少年特发性关节炎患者的健康相关生活质量。 PRINTO跨国生活质量队列研究。

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OBJECTIVES: To compare health-related quality of life (HRQL) and to identify clinical determinants for poor HRQL of patients with juvenile idiopathic arthritis (JIA) coming from three geographic areas. METHODS: The HRQL was assessed through the Child Health Questionnaire (CHQ). A total of 30 countries were included grouped in three geographic areas: 16 countries in Western Europe; 10 in Eastern Europe; and four in Latin America. Potential determinants of poor HRQL included demographic data, physician's and parent's global assessments, measures of joint inflammation, disability as measured by Childhood Health Assessment Questionnaire (CHAQ) and erythrocyte sedimentation rate. Poor HRQL was defined as a CHQ physical summary score (PhS) or psychosocial summary score (PsS) <2 S.D. from that of healthy children. RESULTS: A total of 3167 patients with JIA, younger than 18 yrs, were included in this study. The most affected health concepts (<2 S.D. from healthy children) that differentiate the three geographic areas include physical functioning, bodily pain/discomfort, global health, general health perception, change in health with respect to the previous year, self-esteem and family cohesion. Determinants for poor HRQL were similar across geographic areas with physical well-being mostly affected by the level of disability while the psychosocial well-being by the intensity of pain. CONCLUSION: We found that patients with JIA have a significant impairment of their HRQL compared with healthy peers, particularly in the physical domain. Disability and pain are the most important determinants of physical and psychosocial well-being irrespective of the geographic area of origin.
机译:目的:比较来自三个地理区域的青少年特发性关节炎(JIA)患者的健康相关生活质量(HRQL)并确定不良HRQL的临床决定因素。方法:通过儿童健康问卷(CHQ)评估HRQL。总共将30个国家分为三个地理区域:西欧的16个国家;东欧10个;还有四个在拉丁美洲。 HRQL较差的潜在决定因素包括人口统计学数据,医生和父母的整体评估,关节炎症的测量,通过儿童健康评估问卷(CHAQ)测量的残疾和红细胞沉降率。差的HRQL被定义为CHQ身体综合评分(PhS)或社会心理综合评分(PsS)<2 S.D.从健康的孩子那里。结果:本研究共纳入3167名年龄在18岁以下的JIA患者。受影响最大的健康概念(健康儿童的<2 SD)将三个地理区域区分开来,包括身体机能,身体疼痛/不适,全球健康,总体健康感知,与前一年相比的健康变化,自尊和家庭凝聚。 HRQL差的决定因素在各个地理区域相似,身体健康主要受残障程度影响,而心理社会健康则受疼痛程度影响。结论:我们发现,与健康同龄人相比,JIA患者的HRQL明显受损,尤其是在身体方面。残疾和疼痛是决定身心健康状况的最重要因素,而与原籍地理区域无关。

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