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首页> 外文期刊>Rheumatology >Sjogren's syndrome is associated with and not secondary to systemic sclerosis.
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Sjogren's syndrome is associated with and not secondary to systemic sclerosis.

机译：干燥综合征与系统性硬化症有关，而不是继发于系统性硬化症。

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OBJECTIVES: When Sjogren's syndrome (SS) is secondary to rheumatoid arthritis, the sicca syndrome is less serious and anti-SSA/SSB antibodies are found less frequently than in primary SS (pSS). When SS is associated with systemic lupus erythematosus, clinical and serological patterns are similar to those of pSS. We aimed to determine whether SS, accompanying systemic sclerosis (SSc), could be considered secondary to or associated with SSc and whether the coexistence of both modifies the severity and the outcome of each disease. Patients and METHODS: A retrospective multicentric study was conducted to compare (i) characteristics and complications of SS between 27 patients with SS and SSc (SS-SSc) and 202 patients with pSS, and (ii) the characteristics of SSc and complications between the SS-SSc group and 94 patients with SSc alone. RESULTS: SS features were similar in both SS-SSc and pSS patients, except for peripheral neuropathy and arthritis, which was more common in SS-SSc than in the pSS patients (P= 0.02 and 0.05, respectively). SSc appears to be less severe in patients with SS-SSc than SSc alone with a lower frequency of lung fibrosis (P = 0.05). Compared with patients with pSS or SSc alone, SS-SSc patients were more likely to have another autoimmune disorder and other autoantibodies (SS-SSc vs pSS, P = 0.02 and P = 0.03, respectively). CONCLUSION: SS seems to be associated with and not secondary to SSc. SS associated with SSc has the same features as pSS, but SSc seems to be less serious. Moreover, the association of SS and SSc is frequently accompanied by a spreading of autoimmunity.
机译：目的：当类风湿性关节炎继发干燥综合征（Sjogren's syndrome，SS）时，干燥综合征就不那么严重了，抗SSA / SSB抗体的发生频率也低于原发性SS（pSS）。当SS与系统性红斑狼疮相关时，其临床和血清学模式与pSS相似。我们的目的是确定是否可以将SS及其伴随的系统性硬化症（SSc）视为继发于SSc或与之相关联，以及两者的共存是否会改变每种疾病的严重程度和结果。患者和方法：进行了一项回顾性多中心研究，以比较（i）27例SS和SSc患者（SS-SSc）和202例pSS患者的SS特征和并发症，以及（ii）SSc的特征及其之间的并发症。 SS-SSc组和94例仅SSc的患者。结果：SS-SSc和pSS患者的SS特征相似，除了周围神经病变和关节炎外，SS-SSc的患者比pSS患者更常见（分别为0.02和0.05）。 SS-SSc患者的SSc似乎比单独的SSc轻，肺纤维化的发生率更低（P = 0.05）。与单独使用pSS或SSc的患者相比，SS-SSc的患者更有可能患有另一种自身免疫性疾病和其他自身抗体（SS-SSc vs pSS，分别为P = 0.02和P = 0.03）。结论：SS似乎与SSc相关而不是次要。与SSc关联的SS具有与pSS相同的功能，但SSc似乎不太严重。而且，SS和SSc的结合经常伴随着自身免疫的扩散。

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