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The association of adipokine levels in plasma and synovial fluid with the severity of knee osteoarthritis

机译：血浆和滑液中脂肪因子水平与膝骨关节炎的严重程度相关

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Objective: We sought to determine the association between plasma and SF levels of leptin and adiponectin in patients with knee OA. Methods: Plasma and SF levels of adipokines and soluble leptin receptor (sOB-R) were determined by ELISA in 96 patients with knee OA at different stages, according to Ahlback's classification. Results: Levels of adiponectin, leptin, sOB-R and free leptin in plasma and SF did not differ significantly across categories of OA severity. However, the ratio of SF to plasma leptin was significantly lower in the advanced OA stage compared with early stages of the disease (P = 0.02). After adjustment for sex and BMI, plasma leptin positively correlated with categories of OA severity (r = 0.23, P = 0.02), whereas SF/ plasma leptin negatively correlated with OA stage (r =0.27, P = 0.01). Cluster analysis showed that all men were included in one cluster and distributed in different stages of OA, whereas women formed three clusters with similar BMI, but those who were older and had the highest plasma leptin levels suffered from advanced OA. Conclusion: Plasma leptin positively correlated with the severity of knee OA. The ratio of SF to plasma leptin might be a marker related to the severity of knee OA. Further studies should investigate whether similar associations exist in other joints affected by OA.
机译：目的：我们试图确定膝OA患者血浆与瘦素和脂联素的血浆SF水平之间的关系。方法：根据Ahlback的分类标准，通过ELISA法测定了96例膝关节OA患者不同阶段的血浆脂蛋白和SF水平以及可溶性瘦素受体（sOB-R）。结果：血浆和SF中脂联素，瘦素，sOB-R和游离瘦素的水平在OA严重程度类别之间没有显着差异。然而，与疾病的早期阶段相比，晚期OA阶段的SF与血浆瘦素的比例明显较低（P = 0.02）。调整性别和BMI后，血浆瘦素与OA严重程度呈正相关（r = 0.23，P = 0.02），而SF /血浆瘦素与OA分期呈负相关（r = 0.27，P = 0.01）。聚类分析表明，所有男性都被包括在一个聚类中，并且分布在OA的不同阶段，而女性则形成了三个具有相似BMI的聚类，但是年龄较大且血浆瘦素水平最高的那些患有晚期OA。结论：血浆瘦素与膝骨关节炎的严重程度呈正相关。 SF与血浆瘦素的比例可能是与膝骨OA严重程度相关的标志。进一步的研究应调查在受OA影响的其他关节中是否存在类似的关联。

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