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首页> 外文期刊>Rheumatology >Validity of the Saint George's Respiratory Questionnaire in the evaluation of the health-related quality of life in patients with interstitial lung disease secondary to systemic sclerosis.
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Validity of the Saint George's Respiratory Questionnaire in the evaluation of the health-related quality of life in patients with interstitial lung disease secondary to systemic sclerosis.

机译：在评估系统性硬化继发性间质性肺病患者健康相关生活质量的评估中，圣乔治呼吸问卷的有效性。

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OBJECTIVES: Interstitial lung disease (ILD) profoundly affects the health-related quality of life (HRQoL) in patients with systemic sclerosis (SSc). We tested the validity of the Saint George's Respiratory Questionnaire (SGRQ), a lung-specific HRQoL-evaluation tool, in a population of SSc patients with ILD. METHODS: Twenty-eight consecutive SSc patients with a restrictive pulmonary involvement, defined as a forced vital capacity <80% of the predicted, with no pulmonary hypertension were considered. All the patients filled in the Medical Research Council (MRC) scale for perceived breathlessness, the SGRQ and the Disability Index of the Health Assessment Questionnaire (HAQ DI), and underwent evaluation with complete pulmonary function testing (PFT), 6-minute walk distance (6MWD) and high-resolution computed tomography (HRCT). RESULTS: The SGRQ 'activity' scores inversely correlated with the 6MWD (r = -0.86, P < 0.001) and forced vital capacity percentage of predicted values (r = -0.47) and directly correlated with HRCT (r = 0.41, P < 0.05), MRC (rho = 0.64, P < 0.001) or HAQ DI scores (r = 0.62, P < 0.001), independently of disease duration or subset. On the contrary, HAQ DI scores were influenced by those variables and corrected correlations with 6MWD (r = 0.56, P < 0.001) or HRCT scores (r = 0.36, P = NS) were less strong than those observed with the SGRQ. CONCLUSIONS: The SGRQ, although not specifically designed for scleroderma, is a valid respiratory-specific questionnaire for the evaluation of HRQoL in patients with SSc-related ILD. The SGRQ performs better in relation to exercise capacity and lung imaging than other non-respiratory-specific questionnaires widely used in scleroderma studies. Further studies are needed to address its ability to assess changes over time or in response to therapy.
机译：目的：间质性肺病（ILD）深刻影响全身性硬化症（SSc）患者的健康相关生活质量（HRQoL）。我们在患有ILD的SSc患者中测试了圣乔治呼吸问卷（SGRQ）（一种针对肺的HRQoL评估工具）的有效性。方法：28例连续的SSc患者受累于限制性肺，定义为强制肺活量<预期值的80％，无肺动脉高压。所有患者均填写了医学研究理事会（MRC）量表，用于感觉到的呼吸困难，SGRQ和健康评估问卷的残疾指数（HAQ DI），并通过完整的肺功能测试（PFT），步行6分钟的距离进行了评估（6MWD）和高分辨率计算机断层扫描（HRCT）。结果：SGRQ“活动性”得分与6MWD（r = -0.86，P <0.001）和强迫肺活量百分比预测值（r = -0.47）成反比，与HRCT直接相关（r = 0.41，P <0.05） ），MRC（rho = 0.64，P <0.001）或HAQ DI评分（r = 0.62，P <0.001），与疾病持续时间或疾病亚群无关。相反，HAQ DI分数受那些变量影响，与6MWD（r = 0.56，P <0.001）或HRCT分数（r = 0.36，P = NS）的校正相关性不如SGRQ所观察到的强。结论：SGRQ尽管不是专门针对硬皮病而设计的，但它是一种有效的呼吸特异性问卷，用于评估SSc相关性ILD患者的HRQoL。与在硬皮病研究中广泛使用的其他非呼吸特异性问卷相比，SGRQ在运动能力和肺成像方面表现更好。需要进一步研究以解决其评估随时间变化或对治疗的反应变化的能力。

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