...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Rheumatology >Lack of association of the -463 G/A myeloperoxidase promoter polymorphism with Behcet's disease in Italian patients.
【24h】

Lack of association of the -463 G/A myeloperoxidase promoter polymorphism with Behcet's disease in Italian patients.

机译：-463 G / A髓过氧化物酶启动子多态性与意大利患者的Behcet病缺乏关联。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To investigate potential associations between the -463 G/A myeloperoxidase (MPO) promoter polymorphism and susceptibility to, and clinical expression of, Behcet's disease (BD). METHODS: One hundred and seventy-five Italian patients who satisfied the International Study Group criteria for BD and 235 healthy age- and sex-matched blood donors were genotyped for the -463 G/A promoter polymorphism of the MPO gene by molecular methods. The patients were subgrouped according to the presence or absence of clinical manifestations. RESULTS: The distribution of allele and genotype frequencies of the MPO -463A/G polymorphism did not differ significantly between the BD patients and the healthy controls. Carriers of the -463 A allele (A/A or A/G) [odds ratio (OR) 0.7, 95% confidence interval (CI) 0.5-1.1] and homozygosity for A allele (OR 0.3, 95% CI 0.1-1.3) were less frequent among BD patients than among the controls, but the difference was not statistically significant. No significant associations werefound when BD patients with and those without clinical manifestations were compared. CONCLUSION: Our data suggest that the -463 G/A promoter polymorphism of the MPO gene is not associated with susceptibility to, and clinical expression of, BD in Italian patients.
机译：目的：探讨-463 G / A髓过氧化物酶（MPO）启动子多态性与白塞氏病（BD）的易感性和临床表达之间的潜在关联。方法：通过分子方法对符合国际研究组BD标准的175名意大利患者和235名年龄和性别匹配的健康献血者进行了基因型分型，确定MPO基因的-463 G / A启动子多态性。根据是否存在临床表现将患者分组。结果：BD患者和健康对照者之间MPO -463A / G多态性的等位基因和基因型频率分布无明显差异。 -463 A等位基因的携带者（A / A或A / G）[比值比（OR）0.7，95％置信区间（CI）0.5-1.1]和纯合性（A 0.33，95％CI 0.1-1.3） ）在BD患者中的发生率低于对照组，但差异无统计学意义。比较有和没有临床表现的BD患者时，没有发现明显的关联。结论：我们的数据表明，MPO基因的-463 G / A启动子多态性与BD患者在BD中的易感性及其临床表达无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号