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首页> 外文期刊>Rheumatology >The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus.
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The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus.

机译：系统性红斑狼疮患者尿沉渣中17型T辅助细胞相关细胞因子的基因表达。

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摘要

OBJECTIVE: We studied the role of type 17 Th cells (TH17) in the pathogenesis of SLE. METHODS: We quantified the mRNA expression of IL-17, -23, -27 and retinoic-acid-related orphan receptor (ROR)-gamma, the regulator for the development and function of TH17, in the urinary sediment of 23 subjects with active lupus nephritis, 25 subjects with a history of lupus nephritis in remission, 30 SLE patients with no history of renal involvement and 8 healthy subjects. RESULTS: All three groups of lupus patients had a higher urinary expression of TH17-related cytokines than the controls. However, urinary expression of IL-17 and -27 was found to be inversely correlated with the SLEDAI score (r = -0.252 and -0.258, respectively; P < 0.05 for both). For patients with active lupus nephritis, the histological activity index of kidney biopsy was also found to be inversely correlated with the urinary expression of ROR-gamma (r = -0.447; P = 0.032), IL-17 (r = -0.454; P = 0.029) and IL-23 (r = -0.455; P = 0.029). Urinary expression of IL-17, -23, -27 and ROR was also found to be inversely correlated with the urinary expression of IFN-gamma and T-bet, the key transcription factor of type 1 Th cells. After 6 months of treatment, urinary IL-27 expression rose significantly in patients with complete response (from 2.07 +/- 1.62 to 3.70 +/- 1.69; P = 0.028) but remained unchanged in those with partial or no response (from 2.60 +/- 1.87 to 2.52 +/- 1.94; P = 0.9). CONCLUSIONS: The urinary expression of TH17-related genes is increased in SLE patients. The degree of up-regulation, however, is inversely related to systemic and renal lupus activity, as well as urinary expression of TH1-related genes. Urinary expression of TH17-related genes increased again after successful immunosuppressive treatment of active disease. Our findings suggest a regulatory role of TH17-related cytokines in pathogenesis of lupus nephritis.
机译：目的：我们研究了17型Th细胞（TH17）在SLE发病中的作用。方法：我们定量了23名活跃的受试者尿沉渣中IL-17，-23，-27和视黄酸相关孤儿受体（ROR）-γ（TH17的发育和功能的调节剂）的mRNA表达。狼疮性肾炎，25名有狼疮性肾炎缓解病史的受试者，30名无肾脏受累史的SLE患者和8名健康受试者。结果：三组狼疮患者的尿中TH17相关细胞因子的表达均高于对照组。然而，发现尿液中IL-17和-27的表达与SLEDAI评分呈负相关（r分别为-0.252和-0.258;两者均P <0.05）。对于活动性狼疮性肾炎患者，还发现肾脏活检的组织学活动指数与ROR-γ的尿表达呈负相关（r = -0.447; P = 0.032），IL-17（r = -0.454; P = 0.029）和IL-23（r = -0.455; P = 0.029）。还发现IL-17，-23，-27和ROR的尿表达与1型Th细胞的关键转录因子IFN-γ和T-bet的尿表达呈负相关。治疗6个月后，完全缓解患者的尿IL-27表达显着升高（从2.07 +/- 1.62增至3.70 +/- 1.69; P = 0.028），而部分缓解或无缓解（从2.60 + /-1.87至​​2.52 +/- 1.94; P = 0.9）。结论：SLE患者尿液中TH17相关基因的表达增加。然而，上调的程度与全身性和肾性狼疮活性以及TH1相关基因的尿表达成反比。成功地对活动性疾病进行免疫抑制后，TH17相关基因的尿表达再次增加。我们的研究结果表明TH17相关细胞因子在狼疮性肾炎发病机制中的调节作用。

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