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首页> 外文期刊>Rheumatology >Laser Doppler imaging for assessment of microcirculation in juvenile systemic sclerosis
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Laser Doppler imaging for assessment of microcirculation in juvenile systemic sclerosis

机译：激光多普勒成像技术评估青少年系统性硬化症的微循环

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Objectives: The objectives of this study were to evaluate the dynamic behaviour of digital skin microvascular blood flow before and after cold stimulation using laser Doppler imaging (LDI) in children and adolescents with RP secondary to juvenile systemic sclerosis (JSS), primary RP (PRP) and healthy controls and to compare functional abnormalities measured by LDI with structural microvascular abnormalities evaluated by nailfold capillaroscopy (NFC). Methods: Five JSS patients, five children and adolescents with PRP and five healthy controls matched for gender and age were included. All subjects had NFC performed. Finger blood flow (FBF) was measured using the LDI system (Moor Instruments) at baseline and after cold stimulus (CS). Results: There were a decreased number of capillaries, a greater number of enlarged capillaries and a higher deletion score in JSS patients compared with controls and patients with PRP. The mean baseline FBF was significantly lower in JSS patients compared with controls. There was no difference between the mean baseline FBF in JSS patients compared with patients with PRP. There was a significant decrease in FBF 1 min after CS in all groups followed by blood flow recovery at 20 min after CS in comparison with basal FBF values in controls, but not in JSS and PRP patients. Conclusion: In JSS patients, LDI showed a lower FBF before and after CS compared with healthy controls and may be an objective and sensitive method for the measurement of digital skin blood flow in RP children.
机译：目的：本研究的目的是评估在使用激光多普勒成像（LDI）的儿童和青少年伴有青少年系统性硬化（JSS），原发性RP（PRP）的儿童和青少年冷刺激前后数字皮肤微血管血流的动态行为）和健康对照，并比较LDI测量的功能异常与指甲折叠毛细血管镜（NFC）评估的结构性微血管异常。方法：纳入5名JSS患者，5名PRP儿童和青少年以及5名性别和年龄相匹配的健康对照。所有受试者均进行了NFC。在基线和冷刺激（CS）后，使用LDI系统（Moor Instruments）测量手指血流量（FBF）。结果：与对照组和PRP患者相比，JSS患者的毛细血管数量减少，毛细血管增大数量更大，缺失得分更高。与对照组相比，JSS患者的平均基线FBF显着降低。与PRP患者相比，JSS患者的平均基线FBF没有差异。与对照组相比，CS组术后1 min的FBF显着降低，而CS组20 min的血流恢复较对照组的基础FBF值显着降低，但JSS和PRP患者则没有。结论：在JSS患者中，与健康对照组相比，LDI在CS之前和之后的FBF较低，这可能是一种客观且灵敏的方法来测量RP儿童的数字皮肤血流。

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