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首页> 外文期刊>Rheumatology >Identification of novel autoantibodies to GABAB receptors in patients with neuropsychiatric systemic lupus erythematosus
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Identification of novel autoantibodies to GABAB receptors in patients with neuropsychiatric systemic lupus erythematosus

机译：神经精神性系统性红斑狼疮患者中针对GABA B受体的新型自身抗体的鉴定

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Objective: The gamma-aminobutyric acid type B receptors (GABARB) are G-protein coupled receptors for GABA, the main inhibitory neurotransmitter in the brain. We identified GABARB subunits as candidate antigens in patients with SLE using a random peptide display library. The aim of this study was to investigate the possible link between anti-GABARB antibodies and disease activity and NPSLE. Methods: ELISA was performed with recombinant proteins of GABARB1b and GABARB2 on serum samples from patients with SLE (n = 88), scleroderma (n = 20), myositis (n = 20) or vasculitis (n = 20) as well as healthy subjects (n = 20). Cerebrospinal fluid (CSF) from 23 patients with SLE was also examined. Results: Autoantibodies to GABARBs were exclusive to patients with SLE (P0.001) and positively associated with SLEDAI (anti-GABARB1b, P = 0.001; anti-GABARB2, P0.001). Of note, autoantibodies were positively linked with NPSLE (anti-GABARB1b, P = 0.02; anti-GABARB2, P = 0.03). Moreover, anti-GABARBs was detected in 61.5% of CSF samples from patients with active NPSLE, a frequency that was significantly higher than that for patients with non-SLE syndromes. Conclusion: Anti-GABARB antibodies could represent novel candidate markers for disease activity and NPSLE.
机译：目的：γ-氨基丁酸B型受体（GABARB）是GABA的G蛋白偶联受体，GABA是大脑中主要的抑制性神经递质。我们使用随机肽展示库确定了SABA患者的GABARB亚基为候选抗原。这项研究的目的是研究抗GABARB抗体与疾病活性和NPSLE之间的可能联系。方法：对患有SLE（n = 88），硬皮病（n = 20），肌炎（n = 20）或血管炎（n = 20）以及健康受试者的血清样本中的GABARB1b和GABARB2重组蛋白进行ELISA （n = 20）。还检查了23例SLE患者的脑脊液（CSF）。结果：针对GABARB的自身抗体仅适用于SLE患者（P <0.001），并且与SLEDAI正相关（抗GABARB1b，P = 0.001;抗GABARB2，P <0.001）。值得注意的是，自身抗体与NPSLE正相关（抗GABARB1b，P = 0.02;抗GABARB2，P = 0.03）。此外，在活动性NPSLE患者的脑脊液样本中有61.5％检出了抗GABARBs，其频率明显高于非SLE综合征患者。结论：抗GABARB抗体可以代表疾病活性和NPSLE的新候选标记。

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