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首页> 外文期刊>Rheumatology >Regression of lymphoma after withdrawal of infliximab alone in an infliximab/methotrexate-treated RA patient.
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Regression of lymphoma after withdrawal of infliximab alone in an infliximab/methotrexate-treated RA patient.

机译：在英夫利昔单抗/甲氨蝶呤治疗的RA患者中，单独停用英夫利昔单抗后淋巴瘤消退。

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Sir, The risk of lymphoma in RA patients treated with anti-TNF agents has been debated, with some discrepancy between studies . Previous reports describing tumour regression post-anti-TNF withdrawal have involved concurrent MTX cessation or EBV infection . We describe lymphoma occurring at an unusual site, which regressed on stopping infliximab alone.A 62-year-old man diagnosed with sero-positive RA in 1984 and Crohn's disease in 1988, was initially treated with prednisolone 10mg/day. Active RA prompted multiple disease-modifying drug use, including penicillamine, SSZ, MTX and LEF, all of which failed due to inefficacy or adverse effects. Infliximab with MTX was started in 2002, resulting in a DAS reduction from 8.34 to 3.22 within a month. In June 2009, the patient noticed excessive lacri-mation from his left eye. He was found to have a swelling over the inner canthus of the eye, present for 1 month.
机译：主席先生，在抗TNF药物治疗的RA患者中淋巴瘤的风险一直存在争议，研究之间存在差异。先前描述抗TNF撤药后肿瘤消退的报道涉及并发MTX停止或EBV感染。我们描述了发生在不寻常部位的淋巴瘤，仅在停用英夫利昔单抗后才复发.1984年，一名62岁的男性被诊断患有血清阳性RA，1988年被诊断为克罗恩病，最初接受泼尼松龙10mg /天的治疗。活跃的RA促使人们使用多种可改善疾病的药物，包括青霉素，SSZ，MTX和LEF，这些药物均由于无效或不良反应而失败。英菲利昔单抗与MTX于2002年开始使用，导致DAS在一个月内从8.34降至3.22。 2009年6月，患者注意到左眼有过多流泪。发现他的眼睛内can肿胀，持续了1个月。

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