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首页> 外文期刊>Rheumatology >Clinical significance of high levels of soluble tumour necrosis factor-alpha receptor-2 produced by alternative splicing in rheumatoid arthritis: a longitudinal prospective cohort study.
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Clinical significance of high levels of soluble tumour necrosis factor-alpha receptor-2 produced by alternative splicing in rheumatoid arthritis: a longitudinal prospective cohort study.

机译：在类风湿关节炎中通过选择性剪接产生的高水平可溶性肿瘤坏死因子-α受体2的临床意义：一项纵向前瞻性队列研究。

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OBJECTIVES: We investigated whether serum levels of an alternatively spliced soluble (s)TNF receptor-2 (DS-TNFR2) affected the clinical response to anti-TNF-alpha therapy, classical DMARDs or radiological evidence of disease progression in patients with RA. METHODS: We included 116 patients with RA. Cohort 1: 52 DMARD-naive early RA patients [mean (s.d.) disease duration 8.5 (6.2) months] who started gold salts and MTX therapies. Cohort 2: 64 MTX-resistant established RA patients [144 (107) months] who started infliximab therapy. We evaluated the European League Against Rheumatism (EULAR) response to therapy and the serum levels of DS-TNFR2, sTNFR2 and ACPAs at baseline and at 12 months. In Cohort 1, radiological progression and levels of MMP-1 were also determined. RESULTS: In Cohort 1, 40% of patients had high baseline levels (HL > 50 ng/ml) of DS-TNFR2 with significantly higher RF and ACPA levels than patients with normal levels (NL
机译：目的：我们调查了选择性剪接的可溶性（s）TNF受体2（DS-TNFR2）的血清水平是否影响RA患者抗TNF-α治疗，经典DMARDs或疾病进展的放射学证据的临床反应。方法：我们纳入了116例RA患者。队列1：52例未使用DMARD的RA早期患者[平均病史持续8.5（6.2）个月]，他们开始了金盐和MTX疗法。队列2：开始英夫利昔单抗治疗的64例MTX耐药的RA患者[144（107）个月]。我们评估了欧洲抗风湿病联盟（EULAR）对治疗的反应以及基线和第12个月时血清DS-TNFR2，sTNFR2和ACPA的水平。在队列1中，还确定了放射学进展和MMP-1水平。结果：在队列1中，40％的患者DS-TNFR2的基线水平高（HL> 50 ng / ml），且DS和TNF水平正常（NL

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