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首页> 外文期刊>Rheumatology >Onset age affects mortality and renal outcome of female systemic lupus erythematosus patients: A nationwide population-based study in Taiwan
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Onset age affects mortality and renal outcome of female systemic lupus erythematosus patients: A nationwide population-based study in Taiwan

机译：发病年龄影响女性系统性红斑狼疮患者的死亡率和肾脏结局：台湾一项基于人群的全国性研究

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Objective. The objective of this study was to investigate the impact of disease onset age on mortality and renal survival in female SLE patients. Methods. This nationwide, population-based, retrospective cohort study used data from the National Health Insurance Research Database of Taiwan. Female patients newly diagnosed with SLE from 2001 to 2004 were identified as the study cohort. A non-SLE group was matched for age, sex and initial diagnosis date (index date) as the comparison cohort. Co-morbidities, mortality rates and end-stage renal disease (ESRD) incidences were compared among SLE patients of different onset age. Hazard ratios with a 95% CI were determined by the Cox proportional hazard model to quantify the mortality rates and ESRD incidences. Juvenile-onset, adult-onset and late-onset SLE patients were categorized according to disease onset age: <18, 18-50 and >50 years old. Results. In total, 513 juvenile-onset, 3076 adult-onset and 764 late-onset SLE patients were identified. Compared with non-SLE controls, the hazard ratios of mortality were 6.49 (95% CI 3.73, 11.32, P<0.001) for juvenile-onset, 1.75 (95% CI 1.47, 2.08, P<0.001) for adult-onset and 3.44 (95% CI 2.76, 4.28, P<0.001) for late-onset SLE patients. The hazard ratios of incident ESRD were 20.28 (95% CI 12.79, 32.15, P<0.001) for adult-onset lupus patients and 1.99 (95% CI 1.36, 2.93, P<0.001) for late-onset patients. Conclusion. Female patients with late-onset SLE carried a higher risk of mortality than those with adultonset disease in the presence of co-morbidities. Juvenile-onset SLE patients were at greatest risk of mortality, which is probably due to disease severity.
机译：目的。这项研究的目的是调查疾病发作年龄对女性SLE患者死亡率和肾脏存活率的影响。方法。这项基于人群的全国性回顾性队列研究使用了台湾国家健康保险研究数据库中的数据。 2001年至2004年新诊断为SLE的女性患者被确定为研究队列。将非SLE组的年龄，性别和初始诊断日期（索引日期）进行比较，作为比较队列。比较不同发病年龄的SLE患者的合并症，死亡率和终末期肾脏疾病（ESRD）发生率。通过Cox比例风险模型确定CI为95％的危险比，以量化死亡率和ESRD发生率。根据疾病的发病年龄将青少年发作，成年发作和晚期发作SLE患者分类：<18岁，18-50岁和> 50岁。结果。总共确定了513例青少年发作，3076例成人发作和764例晚期SLE患者。与非SLE对照相比，青少年发病的死亡率危险比为6.49（95％CI 3.73，11.32，P <0.001），成人发病为1.75（95％CI 1.47，2.08，P <0.001）和3.44迟发性SLE患者（95％CI 2.76，4.28，P <0.001）。对于成年狼疮患者，发生ESR​​D的危险比为20.28（95％CI 12.79，32.15，P <0.001），而对于迟发性狼疮患者为1.99（95％CI 1.36，2.93，P <0.001）。结论。在存在合并症的情况下，迟发性SLE的女性患者比成年性疾病的女性具有更高的死亡风险。少年期SLE患者的死亡风险最高，这可能是由于疾病严重程度所致。

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