General approach to a spiro indole-3,1 '-naphthalene tetracyclic system: stereoselective pseudo four-component reaction of isatins and cyclic ketones with two molecules of malononitrile

Elinson M. N.; Vereshchagin A. N.; Nasybullin R. F.; Bobrovsky S. I.; Ilovaisky A. I.; Merkulova V. M.; Bushmarinov I. S.; Egorov M. P.

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General approach to a spiro indole-3,1 '-naphthalene tetracyclic system: stereoselective pseudo four-component reaction of isatins and cyclic ketones with two molecules of malononitrile

机译：螺吲哚-3,1'-萘四环体系的一般方法：靛红和环状酮与丙二腈两个分子的立体选择性假四组分反应

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A new type of catalytic stereoselective cascade pseudo four-component reaction was discovered. The simple and facile pseudo four-component reaction of isatins, cyclic ketones with two molecules of malononitrile catalyzed by triethylamine at ambient temperature stereoselectively results in the formation of tetracyclic spirooxindoles in 60-90% yields. Thus, a new simple and efficient 'one-pot' method to synthesize substituted spirooxindoles was found directly from reasonable starting compounds. Unique stereoselectivety was achieved on two or three centers in this pseudo four-component reaction.

机译：发现了一种新型的催化立体选择性级联伪四组分反应。在室温下，由三乙胺催化的靛红，环酮与两个分子的丙二腈的简单，容易的假四组分反应，立体选择性地以60-90％的产率形成了四环螺并氧杂吲哚。因此，直接从合理的起始化合物中发现了一种新的简单有效的“一锅法”，用于合成取代的螺氧并吲哚。在该假四组分反应中，在两个或三个中心获得了独特的立体选择性。

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《RSC Advances》 |2015年第62期|共4页
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Elinson M. N.; Vereshchagin A. N.; Nasybullin R. F.; Bobrovsky S. I.; Ilovaisky A. I.; Merkulova V. M.; Bushmarinov I. S.; Egorov M. P.;
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1. General approach to a spiro indole-3,1 '-naphthalene tetracyclic system: stereoselective pseudo four-component reaction of isatins and cyclic ketones with two molecules of malononitrile [J] . Elinson M. N., Vereshchagin A. N., Nasybullin R. F., RSC Advances . 2015,第62期

机译：螺吲哚-3,1'-萘四环体系的一般方法：靛红和环状酮与丙二腈两个分子的立体选择性假四组分反应
2. The electrocatalytic cascade assembling of isatins, malononitrile and N-alkyl barbiturates: An efficient multicomponent approach to the spiro[indole-3,5'-pyrano[2,3-d]pyrimidine] framework [J] . Michail N. Elinson, Alexey I. Ilovaisky, Valentina M. Merkulov, Electrochimica Acta . 2008,第28期

机译：靛红，丙二腈和N-烷基巴比妥酸酯的电催化级联组装：螺[吲哚-3,5'-吡喃[2,3-d]嘧啶]骨架的有效多组分方法
3. Diastereoselective synthesis of spiro[carbazole-3,5′-pyrimidines] and spiro[carbazole-3,1′-cyclohexanes] via four-component reaction [J] . Shao-Cong Zhan, Ren-Jie Fang, Jing Sun, Organic & biomolecular chemistry . 2021,第28期

机译：通过四组分反应对螺ε和吡啶酰基 - 吡啶烷基化合物合成螺ε和螺唑-3,1'-环己烷合成
4. Recognition of Cyclic, Acyclic, Exocyclic and Spiro Acetals and Their Isomers via Structurally Diagnostic Ion/Molecule Reactions with the (CH_(3))_(2)N-C~(+)(velence)O Acylium Ion [C] . Mario Benassi Neto, Marcos N. Eberlin ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：通过与（CH_（3））_（2）N-C〜（+）（Velence）O Acylium离子的结构诊断离子/分子反应识别循环，无环，外循环和螺旋缩醛及其异构体的异构体
5. Novel Rearrangements in the Reactions Directed Toward Preparation of Spiro-NN-ketals: Reactions of Naphthalene-18-diamine with Ninhydrin and Isatin [O] . Motoko Akita, Hideyuki Seto, Reiko Aoyama, 2012

机译：定向制备螺-NN-缩酮的反应中的新型重排：萘-18-二胺与茚三酮和Isatin的反应
6. Novel Rearrangements in the Reactions Directed Toward Preparation of Spiro-N,N-ketals: Reactions of Naphthalene-1,8-diamine with Ninhydrin and Isatin [O] . 秋田, 素子, 瀬戸, 秀幸, 青山, 礼子, 2012

机译：定向制备螺-N，N-缩酮的反应中的新型重排：萘-1,8-二胺与茚三酮和Isatin的反应

General approach to a spiro indole-3,1 '-naphthalene tetracyclic system: stereoselective pseudo four-component reaction of isatins and cyclic ketones with two molecules of malononitrile

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