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Pendrin function in airway epithelia

机译:气道上皮中的Pendrin功能

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The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also expressed in the bronchial epithelium following exposure to the T_H2-type cytokines, interleukin (IL)-4 and IL-13. Expression of the transporter is also upregulated in bronchial asthma and chronic obstructive pulmonary disease. Both diseases involve respiratory inflammation leading to tissue destruction/remodeling and decreased airway function, and data so far indicate that increased pendrin expression and/or activity might contribute to their pathogenesis. In this review, we summarize data that have emerged within the past years aimed at revealing the role for pendrin in the airway epithelia.
机译:阴离子交换体Pendrin(SLC26A4)的表达和功能被认为主要限于内耳,肾脏和甲状腺。最近的数据表明,在暴露于T_H2型细胞因子,白介素(IL)-4和IL-13后,pendrin在支气管上皮中也表达。在支气管哮喘和慢性阻塞性肺疾病中,转运蛋白的表达也上调。两种疾病都涉及导致组织破坏/重塑和气道功能降低的呼吸道炎症,迄今为止的数据表明,Pendrin表达和/或活性的增加可能有助于其发病。在这篇综述中,我们总结了过去几年中出现的旨在揭示Pendrin在气道上皮细胞中的作用的数据。

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