Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

Thalluri Kishore; Paul Ashim; Manne Srinivasa Rao; Dev Dharm; Mandal Bhubaneswar

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Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

机译：微波辅助的C端酰胺合成化学选择性有机催化肽醇

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The synthesis of peptide alcohols from peptides bearing C-terminal amide using beta-aminoalcohols is achieved by a simple, efficient, racemization-free (<1.5%), and chemoselective transformation in the presence of cost-effective PTSA (para-toluenesulfonic acid) under microwave irradiation. Peptide alcohols can be synthesized by a standard solid phase peptide synthesis protocol obviating the need for specially designed resin.

机译：在具有成本效益的PTSA（对甲苯磺酸）存在下，通过简单，有效，无外消旋（<1.5％）和化学选择性转化，可使用β-氨基醇从带有C端酰胺的肽合成肽醇。在微波照射下。可以通过标准固相肽合成规程合成肽醇，而无需专门设计的树脂。

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《RSC Advances》 |2014年第88期|共7页
作者
Thalluri Kishore; Paul Ashim; Manne Srinivasa Rao; Dev Dharm; Mandal Bhubaneswar;
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正文语种 eng
中图分类化学;
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专利

1. Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide [J] . Thalluri Kishore, Paul Ashim, Manne Srinivasa Rao, RSC Advances . 2014,第88期

机译：微波辅助的C端酰胺合成化学选择性有机催化肽醇
2. Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7-36) amide. [J] . Chi Y, Zhang H, Huang W, Bioorganic and medicinal chemistry . 2008,第16期

机译：胰高血糖素样肽-1（7-36）酰胺的微波辅助固相合成，聚乙二醇化和生物活性研究。
3. Influence of polar support for the synthesis of large C-terminal peptide aldehyde: application to chemoselective ligation [J] . Lelievre D., Turpin O., El Kazzouli S., Tetrahedron . 2002,第27期

机译：极性载体对合成大型C端肽醛的影响：在化学选择性连接中的应用
4. Microwave-Assisted Synthesis of a Glycine-Rich Difficult Peptide Sequence, the C-terminal Amidated Portion of Acanthoscurrin [C] . Vinicius M.R. Milan, Diego P. Santos, Marda L.A. Temperini American Peptide Symposium . 2011

机译：微波辅助合成富含甘氨酸的难肽序列，C-末端酰胺化部分的Acanthoscurrin
5. Characterization of Local Structures in Layered Niobates Using Solid-State NMR and Rapid Microwave-Assisted Synthesis and Exfoliation of Their Alcohol Grafted Derivatives [D] . Boykin, Joshua Ross. 2017

机译：固态核磁共振和微波接枝的醇接枝衍生物的快速剥落合成，表征层状铌酸盐中的局部结构
6. Development of a Microwave-assisted Chemoselective Synthesis of Oxime-linked Sugar Linkers and Trivalent Glycoclusters [O] . Katherine McReynolds, Dustin Dimas, Grace Floyd, 2019

机译：肟辅助糖连接基和三价糖簇的微波辅助化学选择性合成的研究进展。
7. Substituted Benzhydrylamine Resins in Solid Phase Peptide Synthesis of Peptide Amides and Peptides with C-terminal Asparagine monitored by Potentiometric Titration with Perchloric Acid. Classification of Acid Lability of Different Resins. [O] . Mogens Christensen, Ole Schou, V. S. Pedersen, 1981

机译：取代的苯磺酰胺树脂在固相肽的合成肽酰胺和肽与通过高氯酸的电位滴定监测的C末端天冬酰胺的肽。不同树脂的酸性损伤的分类。

Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

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