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Capillarity-driven (self-powered) one-dimensional photonic crystals for refractometry and (bio) sensing applications

机译:毛细驱动的(自供电)一维光子晶体,用于折射和(生物)传感应用

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摘要

In this work, we advance the state-of-the-art knowledge on photonic crystals by demonstrating the effective and reliable operation of vertical one-dimensional photonic crystals by capillarity, i.e. without the use of external pumps, for self-powered refractometry and label-free (bio)sensing applications. As a proof-of-concept, an all-silicon self-powered drop-and-measure platform exploiting a vertical one-dimensional photonic crystal as a sensing element is fabricated and tested by the capillary infiltration of both ethanol-water mixtures (used as the benchmark for refractometry) and Bovine Serum Albumin (BSA) aqueous solutions at different BSA concentrations (used as the benchmark for biosensing). Excellent analytical performance is achieved for both refractometry and biosensing, in terms of reproducibility and linearity, as well as sensitivity and limit of detection, thus paving the way towards a novel class of self-powered drop-and-measure platforms for chemical/biochemical point-of-care analysis by exploiting the photonic crystals operating under capillary action as label-free transducers.
机译:在这项工作中,我们通过利用毛细作用(即无需使用外部泵)对垂直一维光子晶体进行有效和可靠的操作(即无需使用外部泵)进行自供电验光和标记,从而提高了对光子晶体的最新知识。的(生物)传感应用程序。作为概念验证,制造了一种利用垂直一维光子晶体作为传感元件的全硅自供电式测滴平台,并通过两种乙醇-水混合物的毛细渗透测试了该平台。以及不同BSA浓度的牛血清白蛋白(BSA)水溶液(用作生物传感的基准)。在重现性和线性,灵敏度和检测极限方面,折光率和生物传感都具有出色的分析性能,从而为化学/生化点的新型自供电滴测平台铺平了道路通过利用在毛细管作用下运行的光子晶体作为无标记换能器,进行护理分析。

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