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首页> 外文期刊>Rheumatology >Telomere length in patients with systemic lupus erythematosus and its associations with carotid plaque
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Telomere length in patients with systemic lupus erythematosus and its associations with carotid plaque

机译：系统性红斑狼疮患者端粒长度及其与颈动脉斑块的关系

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Objective: To evaluate telomere length (TL) between patients with SLE and healthy controls and to test if TL is associated with carotid plaque. Methods: A pilot study of 154 patients with SLE and 152 controls was performed from the SOLVABLE (Study of Lupus Vascular and Bone Long-Term Endpoints) cohort. Demographic and cardiovascular disease (CVD) factors were collected at baseline. The presence or absence of plaque was evaluated by B-mode US. Genomic DNA was isolated from whole peripheral blood. TL was quantified using real-time quantitative PCR. Results: SLE women had a short TL compared with healthy controls (4.57 vs 5.44 kb, P = 0.03). SLE women showed shorter TL than controls across all age groups: <35 years (4.38 vs 6.37 kb), 35-44 years (4.52 vs 5.30 kb), 45-54 years (4.77 vs 5.68 kb) and ≥55 years (4.60 vs 4.71 kb). Among patients with SLE and carotid plaque there was a trend towards shorter TL at a younger age and it was significantly lower in the 35- to 44-year age group when compared with controls (P = 0.025). Multiple logistic regression analysis indicated a risk of carotid plaque with older age [odds ratio (OR) 1.09; 95% CI 1.06, 1.12] but not with TL (OR 1.05; 95% CI 0.97, 1.13). Conclusion: SLE women had significantly shorter TL than controls. SLE women trended towards shorter TL at a younger age. When carotid plaque was identified, the younger SLE women had shorter TL. Only older age but not shorter TL was independently associated with carotid plaque. Additional studies are needed to confirm if TL is a novel biomarker for cardiovascular disease in SLE.
机译：目的：评估SLE患者和健康对照者之间的端粒长度（TL），并测试TL是否与颈动脉斑块相关。方法：从SOLVABLE（狼疮血管和骨长期终点研究）队列中对154名SLE患者和152名对照进行了一项初步研究。在基线时收集人口统计学和心血管疾病（CVD）因素。通过B型US评估斑块的存在与否。从全外周血中分离出基因组DNA。 TL使用实时定量PCR进行定量。结果：与健康对照组相比，SLE妇女的TL较短（4.57 vs 5.44 kb，P = 0.03）。在所有年龄段中，SLE妇女的TL均比对照组短：<35岁（4.38 vs 6.37 kb），35-44岁（4.52 vs 5.30 kb），45-54岁（4.77 vs 5.68 kb）和≥55岁（4.60 vs） 4.71 kb）。在患有SLE和颈动脉斑块的患者中，年轻时TL趋于缩短的趋势，与对照组相比，在35至44岁年龄组中显着降低（P = 0.025）。多元logistic回归分析表明，随着年龄的增长，颈动脉斑块的风险[比值比（OR）为1.09; 95％CI 1.06，1.12]，但不使用TL（OR 1.05; 95％CI 0.97，1.13）。结论：SLE妇女的TL明显短于对照组。 SLE妇女在年轻时倾向于TL缩短。当发现颈动脉斑块时，年轻的SLE妇女的TL较短。仅年龄较大但TL较短者与颈动脉斑块独立相关。需要进一步的研究来确认TL是否是SLE中心血管疾病的新型生物标志物。

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