...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Rheumatology >Raised serum prolactin in rheumatoid arthritis: genuine or laboratory artefact?
【24h】

Raised serum prolactin in rheumatoid arthritis: genuine or laboratory artefact?

机译：类风湿关节炎血清催乳素升高：真正的还是实验室的假象？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: Serum prolactin concentrations have been reported as higher, similar or lower in patients with rheumatoid arthritis (RA) compared with control subjects. We investigated whether low biological activity macroprolactin (a prolactin antibody complex), which is detected variably in different prolactin immunoassays, could account for the discrepant total prolactin results reported in RA. METHODS: We compared serum total prolactin and free prolactin in 60 women with RA and 31 female controls. RESULTS: No subject had hyperprolactinaemia or macroprolactinaemia. Serum concentrations of total and free (monomeric) prolactin were higher (P<0.05) in women with RA [mean (s.d.), 225.6 (104.6) and 201.6 (95.4) mU/l respectively] compared with controls [175.0 (68.5) and 154.0 (60.9) mU/l respectively]. CONCLUSIONS: We report higher serum free prolactin concentrations in women with RA compared with control subjects. This result indicates that the higher serum total prolactin levels in patients with RA are theconsequence of increased free prolactin concentrations and are not due to macroprolactin.
机译：目的：类风湿关节炎（RA）患者的血清催乳素浓度据报道与对照组相比更高，相似或更低。我们调查了在不同催乳素免疫测定法中检测到的低生物活性大催乳素（催乳素抗体复合物）是否可以解释RA中报告的总催乳素结果不一致。方法：我们比较了60例RA患者和31例女性对照的血清总催乳素和游离催乳素。结果：没有受试者患有高泌乳素血症或大泌乳素血症。 RA患儿的血清总催乳素和游离（单体）催乳素的浓度高于对照组（分别为175.6（68.5）和225.6（104.6）和201.6（95.4）mU / l，分别为225.6（104.6）和201.6（95.4）mU / l）。 154.0（60.9）mU / l]。结论：我们报告患有RA的女性的血清游离催乳激素浓度高于对照组。该结果表明，RA患者中较高的血清总催乳激素水平是游离催乳素浓度升高的结果，而不是由于大泌乳素引起的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号