The papers in this supplement to Rheumatology have addressed current knowledge of the pathogenesis of SSc and its associated complications, alongside practical issues of disease management. As our colleagues illustrate, the last 10 years of partnership and research have ushered in a new era of progress in the field of SSc. The expansion of our understanding of SSc pathophysiology has, in turn, led to the development of advanced therapies that have improved prognosis and survival. Despite this, considerable challenges remain in developing our understanding of this disease further and in managing patients with SSc.
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