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首页> 外文期刊>Rheumatology >Chimerism in systemic lupus erythematosus--three hypotheses.
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Chimerism in systemic lupus erythematosus--three hypotheses.

机译：系统性红斑狼疮的嵌合体-三种假设。

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Systemic lupus erythematosus (SLE) is an immune-mediated disease characterized by the presence of autoantibodies and a wide array of clinical symptoms. Despite intensive research, the aetiology of SLE is still unknown and is probably multifactorial. Both genetic and environmental factors have been associated with SLE, but these factors alone are insufficient to explain the onset of SLE. Recently, it has been suggested that chimerism plays a role in the pathogenesis of autoimmune diseases, including SLE. Chimerism indicates the presence of cells from one individual in another individual. In an experimental mouse model, the injection of chimeric cells induces a lupus-like disease. In addition, chimerism is found more often in kidneys of women with SLE than in healthy controls. There are several mechanisms by which chimeric cells could be involved in the pathogenesis of SLE. In this review, three hypotheses on the role of chimerism in SLE are discussed. The first two hypotheses describe the possibilities that chimeric cells induce either a graft-vs-host reaction in the host (comparable with reactions seen after bone marrow transplantation) or a host-vs-graft reaction (comparable with reactions seen after solid organ transplantation). The third hypothesis discusses the possible beneficial role chimeric cells may play in repair mechanisms due to their stem cell-like properties. This review provides insights into the mechanisms by which chimerism may be involved in SLE and proposes several lines of inquiry to further investigate chimerism in SLE.
机译：系统性红斑狼疮（SLE）是一种免疫介导的疾病，其特征是存在自身抗体和多种临床症状。尽管进行了深入研究，但SLE的病因仍然未知，可能是多因素的。遗传因素和环境因素均与SLE相关，但仅这些因素不足以解释SLE的发作。最近，已经提出嵌合体在包括SLE在内的自身免疫疾病的发病机理中起作用。嵌合现象表明来自另一个个体的一个个体的细胞的存在。在实验小鼠模型中，嵌合细胞的注射诱导了狼疮样疾病。此外，与健康对照相比，在患有SLE的女性肾脏中更常见发现嵌合现象。嵌合细胞可能参与SLE的发病机制有多种。在这篇综述中，讨论了嵌合论在SLE中的作用的三个假设。前两个假设描述了嵌合细胞在宿主中诱导移植物与宿主反应（与骨髓移植后所见反应相比）或宿主对移植物反应（与实体器官移植后所见反应相比）的可能性。 。第三个假设讨论了嵌合细胞由于其干细胞样特性而在修复机制中可能发挥的有益作用。这篇综述提供了嵌合体可能参与SLE的机制的见解，并提出了几条探究途径以进一步研究SLE中的嵌合体。

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