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首页> 外文期刊>Rheumatology >Non-tuberculous mycobacterial infection in patients with systemic lupus erythematosus.
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Non-tuberculous mycobacterial infection in patients with systemic lupus erythematosus.

机译：系统性红斑狼疮患者的非结核分枝杆菌感染。

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OBJECTIVES: Patients with systemic lupus erythematosus (SLE) are susceptible to opportunistic infections. To examine the clinical manifestations of non-tuberculous mycobacterial (NTM) infections with those of Mycobacterium tuberculosis (MTB) infections in SLE patients. METHODS: Medical records of a cohort of 725 SLE patients were reviewed for previous NTM infections. Demographic characteristics, predisposing factors and clinical outcomes were compared with patients who had previous MTB infections (n = 39). RESULTS: Eleven (nine female and two male) cases were identified (prevalence 1.5%). The mean +/- S.D. age at the time of infection was 42.8 +/- 13.9 yrs, 9.3 +/- 5.8 yrs after the onset of SLE. The mean +/- S.D. time taken from onset of symptoms to the diagnosis of NTM infection was 5.7 +/- 7.2 months. Sites of involvement included skin and soft tissue (n = 8), chest (n = 2) and disseminated infection (n = 1). NTM infections were more likely to involve extrapulmonary sites (P = 0.006), presented in patients with longer lupus disease duration (P < 0.001), occurred in older patients (P < 0.001) and in those who had a higher cumulative dose of prednisolone (P = 0.01) than MTB infections. Using a stepwise logistic regression, disease duration was found to be the only independent predictive factor (P = 0.005) for NTM infections. Ten (25.6%) patients with MTB infections but none of the patients with NTM infections presented concomitantly at the onset of SLE (P = 0.09). There were no differences in the recurrence rate (P = 0.64) and frequency of disseminated infections (P = 0.40) between NTM and MTB infections. CONCLUSIONS: NTM infections tended to develop in SLE patients later in their disease course than MTB infections. A high index of suspicion is required for its diagnosis.
机译：目的：系统性红斑狼疮（SLE）患者易患机会性感染。在SLE患者中检查非结核分枝杆菌（NTM）感染与结核分枝杆菌（MTB）感染的临床表现。方法：回顾了725名SLE患者的病历，以了解先前的NTM感染情况。将人口统计学特征，诱发因素和临床结果与先前曾感染过MTB的患者进行比较（n = 39）。结果：确定了11例（女性9例，男性2例）（患病率为1.5％）。平均值+/- S.D. SLE发作后的感染年龄为42.8 +/- 13.9岁，9.3 +/- 5.8岁。平均值+/- S.D.从症状发作到诊断NTM所花费的时间为5.7 +/- 7.2个月。受累部位包括皮肤和软组织（n = 8），胸部（n = 2）和弥漫性感染（n = 1）。 NTM感染更可能涉及肺外部位（P = 0.006），在狼疮病持续时间较长（P <0.001），老年患者（P <0.001）和泼尼松龙的累积剂量较高的患者中出现（P = 0.006）（P P = 0.01）比MTB感染高。使用逐步逻辑回归，发现疾病持续时间是NTM感染的唯一独立预测因素（P = 0.005）。十名（25.6％）的MTB感染患者，但NTM感染的患者均未在SLE发作时同时出现（P = 0.09）。 NTM和MTB感染的复发率（P = 0.64）和传播感染的频率（P = 0.40）没有差异。结论：SLE患者的NTM感染病程较MTB感染晚。诊断需要高度怀疑。

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