...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Rheumatic diseases clinics of North America >Immunopathogenesis of systemic sclerosis.
【24h】

Immunopathogenesis of systemic sclerosis.

机译：系统性硬化症的免疫发病机制。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The information outlined above can be used to generate a model of the immunopathogenesis of SSc (Fig. 3). This model includes a susceptible host, with age greater than 25 and female gender being risk factors. The model also includes exposure to exogenous agents, which could be different in different individuals and may include inhaled or ingested chemicals or infectious agents. An early event is T-cell activation, with infiltration in the skin and internal organs. Activation of the T cells is a selective process that appears to be influenced by antigen in SSc patients. The importance of a particular T-cell subpopulation may depend upon the organ involved and the stage of the disease. CD4+ T cells predominate in the skin. In contrast, CD8+ T cells are increased in the lungs of patients with alveolitis, where they are oligoclonal, showing evidence of antigen-driven selection. V delta 1+ gamma/delta T cells are increased in both the blood and lungs of SSc patients and also show evidence of selection by antigen. B cells are activated early, with polyclonal activation leading to hypergammaglobulinemia. SSc-specific autoantibodies target DNA topoisomerase I, centromeric proteins, and RNA polymerases I and III. Characteristics of autoantibodies in SSc suggest that the target antigens are presented to the immune system as native molecules or even part of a multiunit complex. There is some homology between viruses and autoantibody targets in SSc, which suggests that molecular mimicry may play a role in initiating the antibody response. Many nonspecific inflammatory cells infiltrate the tissues and show evidence of activation. These include macrophages and monocytes, mast cells, eosinophils, basophils, and natural killer cells. Soluble mediators made by these T cells, B cells, and nonspecific inflammatory cells can activate and damage fibroblasts, endothelial cells, and other vascular cells. The relative importance of the various candidate cytokines, the temporal sequence of their production, and their cellular sources remain largely to be defined. There may be some contribution of direct T-cell cytotoxicity or antibody-dependent cellular cytoxicity to the tissue damage that occurs.
机译：上面概述的信息可用于生成SSc免疫发病机制的模型（图3）。该模型包括年龄大于25岁且女性为危险因素的易感宿主。该模型还包括暴露于外源性物质，这在不同的个体中可能有所不同，并且可能包括吸入或摄入的化学物质或传染性物质。早期事件是T细胞活化，并渗透到皮肤和内部器官。 T细胞的激活是一个选择性过程，似乎受到SSc患者抗原的影响。特定T细胞亚群的重要性可能取决于所涉及的器官和疾病的阶段。 CD4 + T细胞在皮肤中占主导地位。相比之下，肺泡炎患者的肺中CD8 + T细胞是寡克隆的，这表明抗原驱动选择的证据。在SSc患者的血液和肺中，V delta 1+γ/δT细胞均增加，并且还显示出通过抗原进行选择的证据。 B细胞被早期激活，多克隆激活导致高球蛋白血症。 SSc特异性自身抗体靶向DNA拓扑异构酶I，着丝粒蛋白以及RNA聚合酶I和III。 SSc中自身抗体的特征表明，靶抗原作为天然分子或什至是多单位复合物的一部分呈递给免疫系统。病毒与SSc中的自身抗体靶标之间存在某些同源性，这表明分子模拟可能在引发抗体应答中起作用。许多非特异性炎性细胞浸润组织并显示出活化的证据。这些包括巨噬细胞和单核细胞，肥大细胞，嗜酸性粒细胞，嗜碱性粒细胞和天然杀伤细胞。这些T细胞，B细胞和非特异性炎症细胞产生的可溶性介体可以激活和破坏成纤维细胞，内皮细胞和其他血管细胞。各种候选细胞因子的相对重要性，其产生的时间顺序以及它们的细胞来源仍在很大程度上尚待确定。直接T细胞的细胞毒性或抗体依赖性细胞的细胞毒性可能对发生的组织损伤有所贡献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号