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首页> 外文期刊>Rheumatology >Atherogenic serum lipid profile is an independent predictor for gouty flares in patients with gouty arthropathy.
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Atherogenic serum lipid profile is an independent predictor for gouty flares in patients with gouty arthropathy.

机译：动脉粥样硬化性关节​​炎患者中，致动脉粥样硬化的血脂水平是痛风发作的独立预测因子。

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OBJECTIVE: Atherogenic serum lipid profile possesses pro-inflammatory properties and is associated with more active RA. While prevalent in patients with gout, whether atherogenic lipid profile is associated with gouty flares is unknown. This study aims to investigate whether atherogenic serum lipid predicts gouty flares in patients with gout. METHODS: Adult patients (age > or =21 yrs) who suffered from gout were prospectively followed between September 2006 and November 2007 and their demographic, clinical and laboratory data were collected. Episodes of gouty flares over this observation period were recorded and factors predictive of gouty flares were studied by regression models. RESULTS: Of the 100 patients, 80 were men, 65 were ethnic Chinese, 31 were Malay and the rest were Indian and Caucasian. The mean age and duration of gout (+/-S.D.) were 61.9 +/- 14.0 and 6.6 +/- 7.8 yrs, respectively. The mean serum uric acid and creatinine levels were 537.6 +/- 142.8 and 173.6 +/- 119.9 micromol/l, respectively. In univariate analysis, longer duration of gout, higher adjusted mean serum creatinine, lower adjusted mean fasting serum, total cholesterol and high-density lipoprotein cholesterol (HDL-C) levels were associated with gouty flares. After adjustment for potential confounders in multivariate regression models, longer duration of gout and lower adjusted mean fasting serum HDL-C level remained independently predictive of gouty flares. CONCLUSIONS: Low serum high-density lipoprotein cholesterol level was an independent predictor for gouty flares. Whether optimizing serum HDL-C level can benefit patients with gout in terms of reducing gouty flares needs to be addressed by controlled trials.
机译：目的：致动脉粥样硬化的血清脂质谱具有促炎特性，并与RA活跃有关。虽然在痛风患者中普遍存在，但尚不清楚动脉粥样硬化性脂质分布是否与痛风发作有关。这项研究旨在调查致动脉粥样硬化的血清脂质是否可预测痛风患者的痛风发作。方法：对2006年9月至2007年11月期间患有痛风的成年患者（年龄≥21岁）进行随访，收集其人口统计学，临床和实验室数据。记录该观察期的痛风发作次数，并通过回归模型研究痛风发作的预测因素。结果：100例患者中，男性80例，华裔65例，马来人31例，其余为印度裔和白种人。痛风的平均年龄和持续时间分别为61.9 +/- 14.0岁和6.6 +/- 7.8岁。血清尿酸和肌酐的平均水平分别为537.6 +/- 142.8和173.6 +/- 119.9 micromol / l。在单变量分析中，痛风持续时间较长，平均血清肌酐水平较高，平均空腹血清水平较低，总胆固醇和高密度脂蛋白胆固醇（HDL-C）水平与痛风发作相关。在对多元回归模型中的潜在混杂因素进行调整后，痛风的持续时间更长，而调整后的平均空腹血清HDL-C水平较低，仍然可以独立地预测痛风发作。结论：低血清高密度脂蛋白胆固醇水平是痛风发作的独立预测因子。在减少痛风发作方面，优化血清HDL-C水平是否可以使痛风患者受益，需要通过对照试验解决。

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