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首页> 外文期刊>RSC Advances >Coordination behaviour of new open chain and macrocyclic peptidomimetic compounds with copper(II)
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Coordination behaviour of new open chain and macrocyclic peptidomimetic compounds with copper(II)

机译：新的开环和大环拟肽化合物与铜的配位行为（II）

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摘要

Two valine-derived bis(amino amides) ligands have been prepared and fully characterized. Both compounds contain additional functionalities that implement their basicity and their water solubility. Besides, compound 1 is an open chain ligand, while 2 is a macrocycle. Their protonation constants as well as their stability constants for the formation of the corresponding Cu2+ complexes have been determined potentiometrically. Important differences are associated to the macrocyclic effect and to the additional functionalities in the spacer. The presence of an additional amine group and/or the inclusion of a carboxylic side chain in this spacer increase the stabilities of the Cu2+ complexes, suggesting its participation in the interaction with the metal. Thus, 2 is the first pseudopeptidic cyclophane of this family displaying the ability to form highly stable metal complexes in water. UV-Vis and ESI-MS were used for analyzing the complex species detected in the speciation diagram.
机译：已经制备了两种缬氨酸衍生的双（氨基酰胺）配体并进行了充分表征。两种化合物都包含实现其碱性和水溶性的附加功能。此外，化合物1是开链配体，而化合物2是大环。已经通过电位法确定了它们的质子化常数以及用于形成相应的Cu2 +配合物的稳定性常数。重要的差异与大环效应和间隔基的其他功能有关。在该间隔基中存在额外的胺基和/或包含羧基侧链会增加Cu2 +配合物的稳定性，表明其参与了与金属的相互作用。因此，2是该家族的第一个假肽环烷，显示了在水中形成高度稳定的金属配合物的能力。 UV-Vis和ESI-MS用于分析形态图中检测到的复杂物种。

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