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首页> 外文期刊>RSC Advances >In vitro nucleus nanoprobe with ultra-small polyethylenimine functionalized graphene quantum dots
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In vitro nucleus nanoprobe with ultra-small polyethylenimine functionalized graphene quantum dots

机译：具有超小型聚乙烯亚胺官能化石墨烯量子点的体外核纳米探针

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摘要

Graphene quantum dots surface passivated by polyethylenimine (GQDs-PEI) were prepared with a simple solvothermal method. Compared with the unfunctionalized graphene quantum dots (GQDs), the GQDs-PEI were well dispersed with an ultrasmall average diameter of ca. 1.66 nm, and have achieved better optical properties including high quantum yield (53.0%) and narrow emission spectral features which is probably because of the positively charged amines on PEI which facilitated the dispersion of GQDs. By being applied to the bioimaging of MG-63 cells, the GQDs-PEI showed brighter luminescence and minor cytotoxicity. Moreover, the GQDs-PEI are clearly rendered in the nucleus region, which offered a further application in the diagnosis of diseased phenotypes and the targeted therapy of tumour cells.
机译：采用简单的溶剂热法制备了被聚乙烯亚胺（GQDs-PEI）钝化的石墨烯量子点。与未官能化的石墨烯量子点（GQDs）相比，GQDs-PEI具有良好的分散性，平均直径约为1000微米。在1.66 nm处具有更好的光学性能，包括高量子产率（53.0％）和窄发射光谱特征，这可能是由于PEI上带正电荷的胺促进了GQD的分散。通过应用于MG-63细胞的生物成像，GQDs-PEI显示出更明亮的发光和较小的细胞毒性。此外，GQDs-PEI清楚地显示在细胞核区域，这为疾病表型的诊断和肿瘤细胞的靶向治疗提供了进一步的应用。

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