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首页> 外文期刊>RSC Advances >Biologizing titanium alloy implant material with morphogenetically active polyphosphate
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Biologizing titanium alloy implant material with morphogenetically active polyphosphate

机译：用形态发生活性多磷酸盐对钛合金植入物材料进行生物渗漏

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摘要

As a further step towards a new generation of bone implant materials, we developed a procedure for biological functionalization of titanium alloy surfaces with inorganic calcium polyphosphate (Ca-polyP). This polymer has been demonstrated to exhibit morphogenetic activity. The coating of titanium oxidized Ti-6Al-4V scaffolds with biologically active amorphous Ca-polyP microparticles is formed by Ca2+ ion bridges to the silane coupling agent APTMS. This surface is durable and stable as an almost homogeneous Ca-polyP layer onto the metal. The homogenously coated Ca-polyP titanium scaffold was found to be biologically active and supported the growth and functional activity of bone cell-related SaOS-2 cells despite the reduced surface roughness, while the non-modified titanium surfaces are biologically inert. Quantitative qRT-PCR experiments revealed that the Ca-polyP coated titanium alloy markedly increased the steady-state levels of transcripts of the two marker enzymes involved in initiation of bone mineral deposition, the carbonic anhydrase IX and the alkaline phosphatase. The innovative coating of titanium alloy with Ca-polyP offers a promising technique for the fabrication of morphogenetically active bone implants with advantageous mechanical and regeneration-inducing properties.
机译：作为迈向新一代骨植入材料的又一步，我们开发了一种利用无机多磷酸钙（Ca-polyP）对钛合金表面进行生物功能化的程序。已经证明该聚合物表现出形态发生活性。具有生物活性无定形Ca-polyP微粒的钛氧化Ti-6Al-4V支架涂层是通过与硅烷偶联剂APTMS的Ca2 +离子桥形成的。作为金属表面上几乎均质的Ca-polyP层，该表面耐用且稳定。发现均匀涂覆的Ca-polyP钛支架尽管具有降低的表面粗糙度，但具有生物活性并支持骨细胞相关SaOS-2细胞的生长和功能活性，而未改性的钛表面具有生物惰性。定量qRT-PCR实验表明，Ca-polyP涂层钛合金显着提高了参与骨骼矿物质沉积起始的两种标记酶碳酸酐酶IX和碱性磷酸酶的转录物的稳态水平。带有Ca-polyP的创新钛合金涂层为具有良好机械和再生诱导性能的形态发生活性骨植入物的制造提供了一种有前途的技术。

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