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Functionalization of nano-emulsions with an amino-silica shell at the oil-water interface

机译：在油-水界面处具有氨基硅胶壳的纳米乳液的功能化

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Nano-emulsions are very promising nano-carriers with high potential for loading lipophilic drugs. However, the surface of oil nano-droplets is a dynamic oil/water interface stabilized by surfactants, and its chemical modification to graft ligands is highly challenging. In this study we developed a new protocol for modification of the nano-droplets surface through a silica shell terminated by amine functions. It enabled preparation of nanocapsules of 65, 85 and 120 nm diameters with a surface coverage of ca. 2 amino groups per nm(2). The nanocapsule surface was then functionalized (41% efficiency) by a model fluorescent ligand (coumarin blue) with a carboxylic function. The evidence for the successful grafting was provided by spectrofluorometry, Forster resonance energy transfer, atomic force microscopy coupled with fluorescence imaging and fluorescence correlation spectroscopy. This simple protocol for surface functionalization of the liquid/liquid interface of lipid droplets may constitute a real advance regarding potential applications that need efficient decoration of droplets with ligands.
机译：纳米乳剂是非常有前途的纳米载体，具有高负载脂溶性药物的潜力。然而，油纳米滴的表面是由表面活性剂稳定的动态油/水界面，并且其对接枝配体的化学改性具有很高的挑战性。在这项研究中，我们开发了一种通过胺官能团终止的二氧化硅壳修饰纳米液滴表面的新方案。它能够制备直径分别为65、85和120 nm的纳米胶囊，其表面覆盖率约为。每nm 2个氨基（2）。然后通过具有羧基功能的模型荧光配体（香豆素蓝）将纳米胶囊表面功能化（效率为41％）。分光荧光法，Forster共振能量转移，原子力显微镜结合荧光成像和荧光相关光谱学提供了成功嫁接的证据。关于脂质液滴的液体/液体界面的表面功能化的这种简单方案，可以构成关于需要用配体有效装饰液滴的潜在应用的真正进步。

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