Tautomeric transformations of piroxicam in solution: a combined experimental and theoretical study

Ivanova D.; Deneva V.; Nedeltcheva D.; Kamounah F. S.; Gergov G.; Hansen P. E.; Kawauchi S.; Antonov L.

首页> 外文期刊>RSC Advances >Tautomeric transformations of piroxicam in solution: a combined experimental and theoretical study

【24h】

Tautomeric transformations of piroxicam in solution: a combined experimental and theoretical study

机译：吡罗昔康在溶液中的互变异构转化：结合实验和理论研究

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Piroxicam tautomerism was studied in solution by using UV-Vis spectroscopy, NMR measurements and advanced chemometrics. It has been found that in ethanol and DMSO the enol-amide tautomer is present mainly as a sandwich type dimer. The addition of water leads to distortion of the aggregate and to gradual shift of the equilibrium towards the zwitterionic tautomer. Quantitative data for the aggregation and the tautomeric equilibria are presented. Quantum chemical calculations (M06-2X/TZVP) have been used to explain stability of the tautomers as a function of the solvent and concentration.

机译：通过使用紫外-可见光谱，NMR测量和先进的化学计量学对溶液中的吡罗昔康互变异构进行了研究。已经发现在乙醇和DMSO中，烯醇酰胺互变异构体主要以夹心型二聚体存在。加水导致聚集体变形并导致平衡逐渐向两性离子互变异构体转移。给出了聚集和互变异构平衡的定量数据。量子化学计算（M06-2X / TZVP）已用于解释互变异构体的稳定性与溶剂和浓度的关系。

著录项

来源
《RSC Advances》 |2015年第40期|共9页
作者
Ivanova D.; Deneva V.; Nedeltcheva D.; Kamounah F. S.; Gergov G.; Hansen P. E.; Kawauchi S.; Antonov L.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. Tautomeric transformations of piroxicam in solution: a combined experimental and theoretical study [J] . Ivanova D., Deneva V., Nedeltcheva D., RSC Advances . 2015,第40期

机译：吡罗昔康在溶液中的互变异构转化：结合实验和理论研究
2. Composition dependent multiple structural transformations of myoglobin in aqueous ethanol solution: A combined experimental and theoretical study [J] . Ghosh R., Samajdar R. N., Bhattacharyya Aninda Jiban, The Journal of Chemical Physics . 2015,第1期

机译：乙醇水溶液中肌红蛋白的成分依赖性多重结构转化：结合实验和理论研究
3. Composition dependent multiple structural transformations of myoglobin in aqueous ethanol solution: A combined experimental and theoretical study [J] . Ghosh R., Samajdar R. N., Bhattacharyya Aninda Jiban, The Journal of Chemical Physics . 2015,第1期

机译：乙醇水溶液中肌红蛋白的成分依赖性多重结构转化：结合实验和理论研究
4. PREDICTING SOLUTIONS TOWARDS IMPROVED HIGH POWER WHITE LED LIGHT SOURCES - A COMBINED THEORETICAL AND EXPERIMENTAL STUDY [C] . C. Sommer, F. P. Wenzl, L.Kuna, European illumination optics conference . 2008

机译：改进大功率白光LED光源的预测解决方案-理论与实验研究相结合
5. The electrophoretic properties of end -labeled DNA molecules in gels, polymer solutions and free-solutions: A theoretical and experimental study. [D] . Desruisseaux, Claude. 2000

机译：凝胶，聚合物溶液和游离溶液中末端标记的DNA分子的电泳特性：理论和实验研究。
6. Replacement of Oxygen by Sulfur in Small Organic Molecules. 3. Theoretical Studies on the Tautomeric Equilibria of the 2OH and 4OH-Substituted Oxazole and Thiazole and the 3OH and 4OH-Substituted Isoxazole and Isothiazole in the Isolated State and in Solution [O] . Peter I. Nagy 2016

机译：小型有机分子中的硫替代氧。 3. 2OH和4OH取代的恶唑和噻唑与3OH和4OH取代的异恶唑和异噻唑的互变异构平衡的理论研究
7. Tautomeric transformations of piroxicam in solution: a combined experimental and theoretical study [O] . Ivanova, D, Deneva, V, Nedeltcheva, D, 2015

机译：吡罗昔康在溶液中的互变异构转化：结合实验和理论研究

Tautomeric transformations of piroxicam in solution: a combined experimental and theoretical study

摘要

著录项

相似文献

相关主题

期刊订阅