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首页> 外文期刊>RSC Advances >Fabrication of bioactive glass-introduced nanofibrous membranes with multifunctions for potential wound dressing
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Fabrication of bioactive glass-introduced nanofibrous membranes with multifunctions for potential wound dressing

机译：具有生物活性的玻璃纤维引入的纳米纤维膜的多功能制备，可用于潜在的伤口敷料

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Currently, a variety of polymer-based membranes are available, which differ in compositions and microstructures, but are far away from being used in the treatment of chronic, nonhealing wounds. Herein, we design new bioactive glass (BG)-introduced multifunctional gelatin/chitosan (G/C) nanofibrous membranes for chronic wound healing, due to the efficacy of the antibacterial and wound healing properties of chitosan and BG. The water contact angle of the mats increased and the water uptake capacity decreased with an increasing BG content, suggesting that their surface hydrophilicity can be adjusted by the BG component. The biologically active ions were readily released from the mats, which is potentially favorable for infectious wounds. Also, the G/C-BG mats were well tolerated by the surrounding host tissue without causing any inflammation and fully degraded by the subcutaneous tissue of rats after 4 weeks post operation. Therefore, the G/C-BG mats afforded a close biomimicry to the fibrous nanostructure of natural soft tissues to facilitate chronic, nonhealing wound treatment.
机译：当前，可获得各种基于聚合物的膜，其成分和微观结构不同，但是距离用于治疗慢性，不愈合的伤口还很远。本文中，由于壳聚糖和BG的抗菌和伤口愈合特性，我们设计了新的生物活性玻璃（BG）引入的多功能明胶/壳聚糖（G / C）纳米纤维膜，用于慢性伤口愈合。随着BG含量的增加，垫的水接触角增加，吸水能力降低，表明垫的表面亲水性可以通过BG组分来调节。生物活性离子很容易从垫子上释放出来，这对于感染性伤口可能是有利的。另外，术后宿主4周后，周围的宿主组织对G / C-BG垫具有良好的耐受性，而不会引起任何炎症，并且被大鼠的皮下组织完全降解。因此，G / C-BG垫为天然软组织的纤维纳米结构提供了紧密的仿生学，以促进慢性，不愈合的伤口治疗。

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