Cytotoxic saponin poliusaposide from Teucrium polium

Elmasri Wael A.; Hegazy Mohamed-Elamir F.; Mechref Yehia; Pare Paul W.

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Cytotoxic saponin poliusaposide from Teucrium polium

机译：T的Poliusaposide细胞毒性生物碱

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Three saponin glycosides have been isolated and characterized from Teucrium polium L. (Lamiaceae). The compounds were isolated from a MeOH aerial plant extract. The structures were elucidated based on spectroscopic methods including UV, IR, 1D and 2D NMR, and HRESIMS data analyses. The identified compounds were evaluated for anticancer effects against 60 human tumor cell lines (NCI). The triterpene glycoside, poliusaposide C completely inhibited the growth of a breast and colon cancer cell line and partially inhibited the growth of a colon, renal and melanoma cell line. Structure-anticancer activity relationships are discussed.

机译：从Teucrium polium L.（唇形科）中分离并鉴定了三种皂苷苷。从MeOH空中植物提取物中分离出化合物。根据包括紫外，红外，一维和二维核磁共振以及HRESIMS数据分析在内的光谱方法阐明了结构。评价鉴定出的化合物对60种人类肿瘤细胞系（NCI）的抗癌作用。三萜糖苷，多杀菌素C完全抑制乳腺癌和结肠癌细胞系的生长，部分抑制结肠，肾和黑素瘤细胞系的生长。讨论了结构-抗癌活性的关系。

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《RSC Advances》 |2015年第34期|共8页
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Elmasri Wael A.; Hegazy Mohamed-Elamir F.; Mechref Yehia; Pare Paul W.;
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正文语种 eng
中图分类化学;
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1. Cytotoxic saponin poliusaposide from Teucrium polium [J] . Elmasri Wael A., Hegazy Mohamed-Elamir F., Mechref Yehia, RSC Advances . 2015,第34期

机译：T的Poliusaposide细胞毒性生物碱
2. Teucrium Polium Plant Extract Provokes Substantial Cytotoxicity at the Early Stage of Embryonic Development [J] . Shaikha S. Al-Qahdi, Nada Alzohari, Abrar Y. Alsaid, Bosnian Journal of Basic Medical Sciences . 2019,第1期

机译：Teucrium ium植物提取物在胚胎发育的早期会引起大量的细胞毒性。
3. Evaluation of Cytotoxic Effect of Teucrium polium on a New Glioblastoma Multiforme Cell Line (REYF-1) Using MTT and Soft Agar Clonogenic Assays [J] . Hossein Eskandary, Saeed Rajabalian, Touraj Yazdi, International Journal of Pharmacology . 2007,第5期

机译：使用MTT和软琼脂克隆测定法评估Te对新型胶质母细胞瘤多形细胞系（REYF-1）的细胞毒作用
4. A review of acacic acid-type saponins from Leguminosae-Mimosoideae as potent cytotoxic and apoptosis inducing agents [C] . Marie-Aleth Lacaille-Dubois, Dieudonne Emmanuel Pegnyemb, Olivier Placide Note Phytochemical Society of Europe Meeting . 2011

机译：从乳杆菌 - MimoSoideae的皂苷类皂苷作为有效的细胞毒性和凋亡诱导剂的述评
5. Synthesis and cytotoxic activity of diosgenyl saponin analogues. [D] . Kaskiw, Matthew. 2009

机译：薯os皂苷类似物的合成和细胞毒活性。
6. Teucrium polium plant extract provokes substantial cytotoxicity at the early stage of embryonic development [O] . Shaikha S. Al-Qahdi, Nada Alzohari, Abrar Y. Alsaid, 2019

机译：Teucrium polium植物提取物在胚胎发育的早期阶段会引起实质性的细胞毒性
7. Teucrium Polium Plant Extract Provokes Substantial Cytotoxicity at the Early Stage of Embryonic Development [O] . Shaikha S. Al-Qahdi, Nada Alzohari, Abrar Y. Alsaid, 2019

机译：Teucrium polium植物提取物在胚胎发育早期引起大量细胞毒性

Cytotoxic saponin poliusaposide from Teucrium polium

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