Influence of carbon nanomaterial defects on the formation of protein corona

Sengupta Bishwambhar; Gregory Wren E.; Zhu Jingyi; Dasetty Siva; Karakaya Mehmet; Brown Jared M.; Rao Apparao M.; Barrows John K.; Sarupria Sapna; Podila Ramakrishna

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Influence of carbon nanomaterial defects on the formation of protein corona

机译：碳纳米材料缺陷对蛋白质电晕形成的影响

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In any physiological media, carbon nanomaterials (CNM) strongly interact with biomolecules leading to the formation of biocorona, which subsequently dictate the physiological response and the fate of CNMs. Defects in CNMs play an important role not only in material properties but also in the determination of how materials interact at the nano-bio interface. In this article, we probed the influence of defect-induced hydrophilicity on the biocorona formation using micro-Raman, photoluminescence, infrared spectroscopy, electrochemistry, and molecular dynamics simulations. Our results show that the interaction of proteins (albumin and fibrinogen) with CNMs is strongly influenced by charge-transfer between them, inducing protein unfolding which enhances conformational entropy and higher protein adsorption.

机译：在任何生理介质中，碳纳米材料（CNM）与生物分子强烈相互作用，导致形成生物电晕，从而决定了生理反应和CNM的命运。 CNM中的缺陷不仅在材料特性方面起着重要作用，而且在确定材料如何在纳米生物界面处相互作用方面也起着重要作用。在本文中，我们使用微拉曼光谱，光致发光，红外光谱，电化学和分子动力学模拟研究了缺陷诱导的亲水性对生物电晕形成的影响。我们的结果表明，蛋白质（白蛋白和纤维蛋白原）与CNM的相互作用受其间电荷转移的强烈影响，诱导蛋白质展开，从而增强构象熵和更高的蛋白质吸附。

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《RSC Advances》 |2015年第100期|共8页
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Sengupta Bishwambhar; Gregory Wren E.; Zhu Jingyi; Dasetty Siva; Karakaya Mehmet; Brown Jared M.; Rao Apparao M.; Barrows John K.; Sarupria Sapna; Podila Ramakrishna;
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中图分类化学;
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1. Influence of carbon nanomaterial defects on the formation of protein corona [J] . Sengupta Bishwambhar, Gregory Wren E., Zhu Jingyi, RSC Advances . 2015,第100期

机译：碳纳米材料缺陷对蛋白质电晕形成的影响
2. Sulfidation of Ag and ZnO Nanomaterials Significantly Affects Protein Corona Composition: Implications for Human Exposure to Environmentally Aged Nanomaterials [J] . Du Tingting, Shi Guoliang, Liu Fangfei, Environmental Science & Technology . 2019,第24期

机译：Ag和ZnO纳米材料的硫化显着影响蛋白质电晕组成：对人类暴露于环境老化的纳米材料的影响。
3. Influence of the Type of Catalysts on the Formation of a Superhydrophobic Carbon Nanomaterial in Hydrocarbon Flames [J] . G. T. Smagulova, M. Nazhipkyzy, B. T. Lesbaev, Journal of engineering physics and thermophysics . 2018,第3期

机译：催化剂类型对烃火焰中超疏水碳纳米材料形成的影响
4. DEVELOPMENT OF ISOLATION TECHNIQUES AND CAPILLARY ELECTROPHORESIS MASS SPECTROMETRY (CESI-MS) METHODS FOR THE CHARACTERISATION OF NANOMATERIAL PROTEIN CORONAS [C] . Klaus Faserl, Andrew Chetwynd, Iseult Lynch, International Mass Spectrometry Conference . 2018

机译：分离技术的开发和毛细管电泳质谱（CESI-MS）用于表征纳米材料蛋白质coronas的特征
5. Experimental investigation of interactions between proteins and carbon nanomaterials. [D] . Sengupta, Bishwambhar. 2015

机译：蛋白质与碳纳米材料之间相互作用的实验研究。
6. Influence of carbon nanomaterial defects on the formation of protein corona [O] . Bishwambhar Sengupta, Wren E. Gregory, Jingyi Zhu, -1

机译：碳纳米材料缺陷对蛋白质电晕形成的影响
7. Formation of a protein corona influences the biological identity of nanomaterials [O] . Daniel Nierenberg, Annette R. Khaled, Orielyz Flores 2018

机译：蛋白质电晕的形成会影响纳米材料的生物学特性
8. Release of Metal Impurities from Carbon Nanomaterials Influences Aquatic Toxicity [R] . Hull, M. S., Kennedy, A. J., Steevens, J. A., 2009

机译：碳纳米材料中金属杂质的释放影响水生毒性

Influence of carbon nanomaterial defects on the formation of protein corona

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