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Synovial joint fluid cytokine levels in hip disease

机译：髋关节疾病滑膜关节液细胞因子水平

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Objective. The purpose of this study was to evaluate cytokine level characteristics in the hip joint fluid, including rapidly destructive coxopathy (RDC), OA, osteonecrosis (ON) of the femoral head and RA. Methods. Thirty-three hips with RDC, 57 with OA, 36 with ON and 10 with RA were included in the study. OA hips were divided into two groups: 20 hips with early OA without joint space narrowing and 37 hips with terminal OA. ON hips were divided into three groups: 13 hips with <3mm collapse, 14 hips with >3mm collapse and 9 hips with terminal ON. Joint fluid was collected during surgery. Cytokine levels including IL-1β, IL-6, IL-8 and TNF-α were measured using homogeneous time-resolved fluorescence. Results. All measured cytokine levels in RDC were significantly higher than those in OA (P<0.05). Terminal OA showed higher cytokine levels than those in early OA (P<0.05). IL-6 and TNF-α levels in the ON group with >3mm collapse were higher than those found in the ON group with <3mm collapse. In comparing cytokine levels between RDC, terminal OA, RA and terminal ON, RDC showed significantly higher IL-8 levels than terminal OA and RA (P<0.05). Conclusion. IL-8 levels in RDC were higher than in the other hip diseases. The IL-8 level may reflect the aggressiveness of joint destruction in RDC, and IL-6 and TNF-α levels may also reflect ongoing destruction in OA and ON.
机译：目的。这项研究的目的是评估髋关节液中的细胞因子水平特征，包括快速破坏性髋病（RDC），OA，股骨头坏死（ON）和RA。方法。该研究包括RDC的33髋，OA的57髋，ON的36髋和RA的10髋。 OA髋分为两类：20例早期OA，无关节间隙变窄，37例末端OA。 ON髋分为三组：塌陷度小于3mm的13髋，塌陷度大于3mm的14髋和末端ON的9髋。手术期间收集关节液。使用均相时间分辨荧光测量了细胞因子水平，包括IL-1β，IL-6，IL-8和TNF-α。结果。 RDC中所有测得的细胞因子水平均显着高于OA中的细胞因子水平（P <0.05）。终末OA显示出比早期OA更高的细胞因子水平（P <0.05）。塌陷> 3mm的ON组的IL-6和TNF-α水平高于塌陷<3mm的ON组。在比较RDC，末端OA，RA和末端ON之间的细胞因子水平时，RDC的IL-8水平显着高于末端OA和RA（P <0.05）。结论。 RDC中的IL-8水平高于其他髋部疾病。 IL-8水平可能反映了RDC中关节破坏的侵略性，IL-6和TNF-α水平也可能反映了OA和ON中持续的破坏。

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